【摘要】 【目的】分析棕榈酸帕利哌酮注射液对社区精神分裂症患者疾病家庭负担及康复等效果的影响。【方法】随机抽取上海市446名使用棕榈酸帕利哌酮注射液的精神分裂症患者，分别采用疾病家庭负担量表、药物治疗依从性简明评定量表、治疗满意度VAS100评分、生存质量测定量表简表、社会功能缺陷筛选量表进行治疗前后的评价，分析患者使用棕榈酸帕利哌酮注射液效果。采用SPSS 26.0软件进行数据统计分析。【结果】使用棕榈酸帕利哌酮注射液后，患者的疾病家庭负担量表总分（13.94±12.17）、家庭日常活动得分（3.26±2.74）、家庭娱乐活动得分（2.21±2.30）、家庭关系得分（2.79±2.76）均明显优于治疗前（14.98±12.64、3.51±2.88、2.48±2.38、3.11±2.87），差异有统计学意义（P<0.05）。使用棕榈酸帕利哌酮注射液后，世界卫生组织生存质量测定量表简表得分（62.89±11.94）、药物治疗依从性简明评定量表得分（28.11±5.64）均优于治疗前（60.67±12.62、27.37±6.96），差异有统计学意义（P<0.05）。与使用棕榈酸帕利哌酮注射液前相比，使用后患者的住院人数显著降低（P<0.01）。【结论】棕榈酸帕利哌酮注射液对精神分裂症作用显著，能有效减轻患者的疾病家庭负担，提高患者生存质量，提升患者药物依从性，降低患者住院率，保障长期治疗效果和促进疾病康复。更多还原

【Abstract】 [Objective] To explore the effect of paliperidone palmitate treatment on schizophrenic patients in the community. [Methods] 446 schizophrenic patients who used paliperidone palmitate injection were selected in Shanghai. Before and after the treatment, the disease family burden scale, the concise evaluation scale of drug treatment compliance, the VAS100 score of treatment satisfaction, the short form of quality of life measurement scale, and the screening scale of social function defects were used to evaluate the effects of paliperidone palmitate injection.The data were statistically analyzed using SPSS 26.0 software. [Results] After using paliperidone palmitate injection, the total score of family burden(13.94±12.17), the score of daily family activities(3.26±2.74), the score of family entertainment activities(2.21±2.30), and the score of family relationship(2.79±2.76) were significantly higher than those before the treatment(14.98±12.64, 3.51±2.88, 2.48±2.38, 3.11±2.87, respectively, all with P<0.05). The scores of the World Health Organization on quality of life brief scale(62.89±11.94) and the medication compliance scale(28.11±5.64) were better than those before treatment(60.67±12.62 and 27.37±6.96, all with P<0.05). Compared with the prior treatment without paliperidone palmitate injection, the number of readmissions after treatment was significantly reduced(P<0.01). [Conclusion] The treatment of paliperidone palmitate injection has significant effect, which can effectively reduce the disease family burden of Schizophrenic patients, improve their quality of life, enhance their drug compliance, reduce the readmission rate of patients, ensure long-term treatment effect and promote disease recovery.更多还原