【摘要】 目的 ：研究右旋酮洛芬氨丁三醇在阻生牙拔除术中的超前镇痛作用。方法 ：选取拔除双侧下颌阻生牙的患者20例，通过随机自身对照原则，将两侧阻生牙分为右旋酮洛芬氨丁三醇组（试验组）与安慰剂组（对照组）。通过数值评定量表(numeric rating scale,NRS)统计患者在拔牙术后0.5、2、4、8、12、24 h疼痛评分，记录24 h内使用应急镇痛药物的总剂量，COX分析法比较患者2次术后首次应用应急镇痛药物的间隔时间及例数，绘制生存曲线。采用SPSS20.0软件包对数据进行统计学分析。结果：手术后2、4、8、12 h，试验组患者术后疼痛的NRS评分显著低于对照组（P<0.05）,24 h试验组使用应急镇痛药物剂量显著低于对照组（P<0.05）。生存曲线表明，试验组首次应用镇痛药物的间隔时间显著长于对照组（P<0.05）。结论：右旋酮洛芬氨丁三醇用于阻生牙拔除术的超前镇痛时，12 h内可取得明显的止疼作用，但12小时后镇痛效果不明显。更多还原

【Abstract】 PURPOSE: To study the preemptive analgesic effect of dexketoprofen tromethamine in extraction of impacted teeth. METHODS: Twenty patients with bilateral mandibular impacted teeth were selected, and were randomly divided into dexketoprofen tromethamine group(experimental group) and placebo group(control group). The pain scores of patients at 0.5, 2, 4, 8, 12, and 24 hours after tooth extraction were counted by numeric rating scale(NRS), and the total dosage of emergent analgesic drugs used in 24 hours was recorded. COX analysis method was used to compare the interval time and the number of cases of first application of emergent analgesic drugs after two operations, and the survival curve was drawn.SPSS 20.0 software package was used for data analysis. RESULTS: The NRS scores of postoperative pain in the experimental group were significantly lower than those in the control group at 2, 4, 8 and 12 hours after operation(P<0.05). The dose of emergent analgesics used in the experimental group for 24 h was significantly lower than that in the control group(P<0.05). Survival curve showed that the interval time between the first application of analgesics in the experimental group was significantly longer than that in the control group(P <0.05). CONCLUSIONS: Dexketoprofen tromethamine can achieve obvious analgesic effect within 12 hours, but the analgesic effect is not obvious after 12 hours.更多还原