【摘要】 目的：探讨白细胞介素6(IL-6)和β连环蛋白（β-catenin）在口腔鳞癌（OSCC）中的表达及临床病理学意义。方法 ：应用化学发光分析法检测110例OSCC患者和109例健康对照者的血清IL-6浓度；应用免疫组织化学检测68例接受手术治疗的OSCC患者肿瘤标本及6例正常黏膜组织中IL-6和β-catenin的表达水平，分析其与临床病理参数之间的相关性及预后价值。采用SPSS 22.0软件包对数据进行统计学分析。结果：化学发光分析显示OSCC患者血清IL-6含量显著增高（P<0.001)。免疫组织化学染色显示，IL-6在OSCC组织中高表达，与颈淋巴结转移（P=0.017）、病理分化程度（P=0.014）、复发和远处转移（P=0.048）显著相关。Kaplan-Meier生存分析表明，IL-6高表达的OSCC患者预后不良。多因素Cox回归分析表明，IL-6高表达是OSCC患者的独立预后危险因素（P<0.05）。β-catenin高表达与病理分化有关（P=0.006），与OSCC患者的预后较差有关。Spearman相关性分析显示，IL-6与β-catenin在OSCC中的表达呈显著正相关（P<0.001）。结论：血清IL-6可作为诊断OSCC的生物标志物，组织中IL-6和β-catenin的表达可以作为评估OSCC患者预后不良的标志物。更多还原

【Abstract】 PURPOSE: To investigate the expression of interleukin-6(IL-6) and β-catenin in oral squamous cell carcinoma(OSCC) and its clinicopathological significance. METHODS: The serum IL-6 concentration in 110 OSCC patients and 109 healthy controls were determined by chemiluminescence analysis. IL-6 and β-catenin expression levels in 68 tumor specimens of OSCC patients undergoing surgical treatment and 6 normal mucosal tissues were determined by im-munohistochemistry method. The correlation between IL-6 and β-catenin and clinicopathological parameters and their prognostic value were analyzed. SPSS 22.0 software package was used for data analysis. RESULTS: Chemiluminescence method showed that the serum IL-6 content of OSCC patients was significantly increased(P<0.001). Immunohistochemical results demonstrated that high expression of IL-6 in OSCC tissues was remarkably associated with cervical lymph node metastasis(P=0.017), pathological differentiation(P=0.014), recurrence and distant metastasis(P=0.048). OSCC patients with high IL-6 expression showed a poor prognosis by Kaplan-Meier survival analysis. Multivariate Cox regression analysis showed that high expression of IL-6 was an independent risk factor affecting the prognosis of patients with OSCC(P<0.05).β-catenin hyperexpression was associated with pathological differentiation(P=0.006) and overall poor survival in OSCC patients. Spearman correlation analysis showed a positive correlation between IL-6 and β-catenin expression in OSCC(P<0.001). CONCLUSIONS: Serum IL-6 is expected to be a biomarker for detection of OSCC, and IL-6 and β-catenin expression in tumour tissues can be used as markers to evaluate the poor prognosis of OSCC.更多还原