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芎芍胶囊治疗动脉粥样硬化作用机制的研究进展
Research progress on the mechanism of Xiongshao Capsules in the treatment of atherosclerosis
【摘要】 动脉粥样硬化(AS)是心脑血管疾病主要的病理基础,近年来AS的发病机制研究逐步深入,诊治手段也不断更迭。活血消瘀制剂芎芍胶囊是陈可冀院士根据复方血府逐瘀汤精简制成,主要由川芎与赤芍组成,对AS、血脂异常、PCI术后再狭窄及冠心病等疗效显著,安全性高,但其具体机制目前仍不明朗。本文对芎芍胶囊治疗AS的基础与临床研究进展进行综述,以期为临床治疗AS的合理用药提供科学依据。
【Abstract】 Atherosclerosis(AS) is the main pathological basis of cardiovascular and cerebrovascular diseases.In recent years, the pathogenesis of AS has been progressively researched and the diagnostic and therapeutic tools have been constantly changed.Xiongshao Capsules, a blood activating and blood stasis eliminating preparation, is made by Academician Chen Keji based on the Compound Xuefu Zhuyu Decoction and is mainly composed of Chuanxiong and Radix Paeoniae.It has significant efficacy and high safety in treating AS,dyslipidemia, restenosis after PCI,and coronary heart disease, but its specific mechanism is still unclear.This article reviewed the basic and clinical research progress of Xiongshao Capsules in the treatment of AS,with a view to providing scientific basis for the rational use of drugs in the clinical treatment of AS.
【Key words】 Xiongshao Capsules; Atherosclerosis; Coronary heart disease; Promote blood circulation and remove blood stasis;
- 【文献出处】 药学研究 ,Journal of Pharmaceutical Research , 编辑部邮箱 ,2023年09期
- 【分类号】R285
- 【下载频次】6