【摘要】 目的：探究清心化痰汤联合颈椎稳定性训练对痰热上扰型颈性眩晕患者椎-基底动脉血流及缺氧诱导因子(HIF-1α)、内皮素(ET)表达的影响。方法：选取本院2016年6月～2018年5月收治的60例痰热上扰型颈性眩晕患者，按照随机抽签法分为治疗组和对照组各30例。对照组给予悬吊疗法及颈椎稳定性训练，治疗组在对照组的基础上给予清心化痰汤治疗痰热上扰型颈性眩晕。比较2组治疗后总有效率，治疗前后颈性眩晕症状与功能评估量表评分、眩晕障碍调查量表评分，内皮素(ET)、C反应蛋白(CRP)、缺氧诱导因子(HIF-1α)水平，血液流变学情况(血浆粘度、全血高切粘度、全血低切粘度),椎基底动脉平均血流速度指标[左侧椎动脉(LVA)、右侧椎动脉(RVA)、椎-基底动脉(VB)]。结果：治疗组治疗总有效率90.00%显著高于对照组63.33%(P<0.05)。治疗后，2组颈性眩晕症状与功能评估量表评分、LVA、RVA、VB较治疗前均显著升高(P<0.05),且治疗组显著高于对照组(P<0.05);2组眩晕障碍调查量表评分、ET、CRP、HIF-1α水平、血浆粘度、全血高切粘度、全血低切粘度较治疗前均显著降低(P<0.05),且治疗组显著低于对照组(P<0.05)。结论：清心化痰汤联合颈椎稳定性训练治疗痰热上扰型颈性眩晕效果较好，可有效改善患者临床症状，减少血液粘稠度，增加颈部血流速度，降低血清学水平，提高抗氧能力。更多还原

【Abstract】 Objective: To explore the effects of Qingxin Huatan Decoction combined with cervical stability training on the blood flow of vertebrobasilar artery and the expressions of hypoxia inducible factor(HIF-1α) and endothelin(ET) in patients with cervical vertigo(syndrome of upward disturbance of phlegm-heat).Methods: From June 2016 to May 2018, 60 patients with cervical vertigo disturbed cervical vertigo(syndrome of upward disturbance of phlegm-heat)were selected and randomly divided into treatment group and control group, with 30 cases in each group.The control group was given suspension therapy and cervical stability training, and the treatment group was treated with Qingxin Huatan Decoction on the basis of the control group.The total effective rate, the scores of Cervical Vertigo Symptom and Function Assessment Scale, the dizziness handicap inventory score, the levels of Endothelin(ET), C-reactive protein(CRP) and hypoxia inducible factor(HIF-1α), hemorheology(plasma viscosity, whole blood high shear viscosity, whole blood low shear viscosity), average blood flow velocity indexes of vertebrobasilar artery [left vertebral artery(LVA), right vertebral artery(RVA), vertebral basilar artery(VB)] were compared between the two groups before and after treatment.Results The total effective rate of the treatment group was 90.00%, which was significantly higher than that of the control group(63.33%)(P<0.05).After treatment, the cervical vertigo symptoms and functional assessment scale score, LVA, RVA and VB were significantly higher than those before treatment(P<0.05), and those in the treatment group was significantly higher than those in the control group(P<0.05); the dizziness handicap inventory score, ET, CRP, HIF-1α level, plasma viscosity, whole blood high shear viscosity and whole blood low shear viscosity in the two groups were significantly lower than those before treatment(P<0.05), and those in the treatment group was significantly lower than those in the control group(P<0.05).Conclusions Qingxin Huatan Decoction combined with cervical stability training is effective in the treatment of cervical vertigo(syndrome of upward disturbance of phlegm-heat).It can effectively improve the clinical symptoms, reduce the blood viscosity, increase the neck blood flow speed, reduce serology level and improve anti-oxidation ability.更多还原