节点文献
微针介导PDRN纳米脂质体的皮肤渗透性能及抗衰功效研究
Microneedle-mediated polydeoxyribonucleotide nanoliposomes for skin penetration performance and anti-aging efficacy
【摘要】 研究微针介导的多聚脱氧核糖核苷酸(PDRN)经皮输送纳米脂质体(PDRN-NLPS)的皮肤渗透性能及皮肤抗衰功效。PDRN-NLPS的粒径为(50.1±0.2)nm,PDI为0.267±0.008,Zeta电位为(-30.2±0.8) mV。透皮研究表明,微针具有很好的透皮给药效果,纳米脂质体在微针的介导下能够有效促进活性成分快速渗透进入皮肤。细胞抗衰功效研究表明,与游离PDRN溶液比较,PDRN-NLPs显著提高SOD活力、显著增加GSH含量及显著降低MDA水平(P <0.05或P <0.01);能够显著提高Col Ⅰ、Col Ⅲ、HA的分泌水平(P <0.05或P <0.01)。
【Abstract】 The skin penetration properties and skin anti-aging efficacy of microneedle-mediated transdermal delivery of polydeoxyribonucleotide nanoliposomes(PDRN-NLPs) were investigated. The particle size of PDRN-NLPs was(50.1 ± 0.2) nm, the PDI was 0.267 ± 0.008, and the Zeta potential was(-30.2 ± 0.8) mV. The nanoliposomes, mediated by the microneedles, could effectively facilitate the rapid penetration of active ingredients into the skin. Cellular anti-aging efficacy studies showed that PDRN-NLPs significantly increased SOD activity, significantly increased GSH content and significantly decreased MDA level compared with the free component solution(P < 0.05 or P < 0.01). It significantly increased the secretion levels of Col I, Col III and HA(P < 0.05 or P < 0.01).
【Key words】 polydeoxyribonucleotide; nanoliposome; microneedle; skin penetration property; anti-aging effect;
- 【文献出处】 日用化学品科学 ,Detergent & Cosmetics , 编辑部邮箱 ,2023年09期
- 【分类号】TQ658
- 【下载频次】44