【摘要】 【目的】观察雷火灸治疗肾阳虚型变应性鼻炎发作期的临床疗效。【方法】将128例肾阳虚型变应性鼻炎发作期患者随机分为对照组和观察组，每组各64例，对照组给予健康宣教及常规方案治疗，观察组在对照组治疗的基础上，给予雷火灸治疗。1周为1个疗程，连续治疗3个疗程。治疗3周后，评价2组临床疗效，观察2组患者治疗前后鼻部症状总评分（TNSS）的变化情况，以及体征评分、中医证候积分、鼻结膜炎生活质量调查问卷（RQLQ）评分的变化情况。比较2组患者治疗前后血清T淋巴细胞亚群（CD3~+、CD4~+、CD8~+、CD4~+/CD8~+）、白细胞介素2(IL-2）、白细胞介素4(IL-4）和免疫球蛋白E(IgE）水平的变化情况。【结果】（1）治疗后，2组患者的鼻塞、喷嚏、流涕、鼻痒评分及TNSS总分均明显改善（P<0.05），且观察组明显优于对照组，差异均有统计学意义（P<0.05）。（2）治疗后，2组患者的体征评分、中医证候积分、RQLQ评分均明显改善（P<0.05），且观察组明显优于对照组，差异均有统计学意义（P<0.05）。（3）治疗后，2组患者的CD3~+、CD4~+、CD8~+、CD4~+/CD8~+均明显改善（P<0.05），且观察组明显优于对照组，差异均有统计学意义（P<0.05）。（4）治疗后，2组患者的IL-2、IL-4、IgE水平均明显改善（P<0.05），且观察组改善明显优于对照组，差异均有统计学意义（P<0.05）。（5）观察组总有效率为90.63%(58/64），对照组为76.56%(49/64）。观察组疗效优于对照组，差异有统计学意义（P<0.05）。【结论】雷火灸治疗肾阳虚型变应性鼻炎发作期可以明显地缓解患者的临床症状，调节免疫功能，并减轻变态反应，从而提高患者的生活质量，疗效显著。更多还原

【Abstract】 Objective To observe the clinical efficacy of thunder-fire moxibustion in treating the exacerbation of allergic rhinitis of kidney-yang deficiency syndrome type.Methods A total of 128 patients with allergic rhinitis of kidney-yang deficiency type were randomly divided into the control group and observation group,with 64 cases in each group.The control group was given health education and conventional treatment,and the observation group was given thunder-fire moxibustion treatment on the basis of the treatment of the control group.One week was a course of treatment,and the treatment lasted for 3 consecutive courses.After 3 weeks of treatment,the clinical efficacy of the two groups was evaluated,and the changes in the Total Nasal Symptom Score(TNSS),as well as the changes in the physical symptom score,traditionl Chinese medicine (TCM) syndrome score and rhinoconjunctivitis quality of life questionnaire(RQLQ)scores were observed before and after treatment.The changes in serum T-lymphocyte subsets(CD3~+,CD4~+,CD8~+,CD4~+/CD8~+),interleukin-2(IL-2),interleukin-4(IL-4)and immunoglobulin E(IgE)levels were compared before and after treatment in the two groups.Results(1)After treatment,the scores of nasal congestion,sneezing,runny nose,itchy nose and total TNSS scores of patients in the two groups were all significantly improved(P<0.05),and the observation group was significantly superior to that of the control group,and the differences were all statistically significant(P<0.05).(2)After treatment,the sign scores,TCM syndrome scores and RQLQ scores of patients in the two groups were all significantly improved(P<0.05),and the observation group was significantly superior to that of the control group,and the difference was statistically significant(P<0.05).(3)After treatment,the CD3~+,CD4~+,CD8~+and CD4~+/CD8~+of the patients in both groups were significantly improved(P<0.05),and the observation group was significantly superior to the control group,and the difference was statistically significant(P<0.05).(4)After treatment,the levels of IL-2,IL-4 and IgE in both groups were significantly improved(P<0.05),and the observation group was significantly superior to the control group,and the difference was statistically significant(P<0.05).(5)The total effective rate was 90.63%(58/64)in the observation group and 76.56%(49/64)in the control group.The efficacy of the observation group was superior to that of the control group,and the difference was statistically significant(P<0.05).Conclusion Thunder-fire moxibustion can significantly relieve clinical symptoms,regulate immune function and reduce allergic reactions during the exacerbation of allergic rhinitis of the kidney-yang deficiency type,thereby improving the patient’s quality of life with remarkable efficacy.更多还原