【摘要】 目的 探讨人乳头状瘤病毒（HPV）16/18型感染与前列腺癌（PCa）发病、分期、淋巴结转移及肿瘤标志物的相关性。方法 选取2019年10月-2021年6月在南阳市中心医院治疗的PCa患者72例作为观察组，同时选取80例前列腺增生患者作为对照组。检测两组HPV16/18型感染情况，同时分析HPV16/18型感染与PCa患者临床病理、预后的关系。结果 观察组HPV16、HPV18感染以及HPV16/18总感染率分别为23.61%、19.44%和43.06%，明显高于对照组2.50%、3.75%和6.25%，差异均有统计学意义（χ~2=15.441、9.397、28.401,P均<0.05）。前列腺特异性抗原（PSA）水平>20 ng/mL、TNM分期Ⅲ～Ⅳ、Gleason评分≥7分、有淋巴结转移患者HPV16/18总感染率分别为60.47%、58.97%、77.78%和55.81%，明显高于PSA水平≤20 ng/mL、TNM分期Ⅰ～Ⅱ、Gleason评分<7分、无淋巴结转移患者，差异均有统计学意义（χ~2=13.198、8.795、21.243、7.088,P均<0.05）。HPV16/18总感染率与PSA水平、TNM分期、Gleason评分及淋巴结转移成正相关（rs=0.428、0.349、0.543、0.313,P均<0.05）。HPV16/18感染和未感染PCa患者中位无进展生存期分别为27个月（95%CI:25.04～28.96）和28个月（95%CI:25.17～30.83），差异无统计学意义（χ~2=0.244,P=0.622）。结论 PCa患者HPV16/18型感染率增加，与患者PSA水平、TNM分期、Gleason评分及淋巴结转移存在相关性，但与患者无进展生存期无明显关系。更多还原

【Abstract】 Objective To investigate the relationship between human papillomavirus(HPV)16/18 infection and the onset,stage,lymph node metastasis and tumor markers of prostate cancer(PCa). Methods 72 patients with PCa treated from October 2019 to June 2021 were selected as the observation group,and 80 patients with benign prostatic hyperplasia were selected as the control group. The HPV16/18 infection of the two groups was detected,and the relationship between HPV16/18 infection and the clinical pathology and prognosis of PCa patients was analyzed. Results The infection rates of HPV16,HPV18 and HPV16/18 in the observation group were 23.61%,19.44% and 43.06%,respectively,which were significantly higher than those in the control group（χ~2=15.441,9.397,28.401,all P<0.05）. The total infection rate of HPV16/18 in patients with prostate-specific antigen(PSA)level >20 ng/mL,TNM stage Ⅲ-Ⅳ,Gleason score ≥7,and lymph node metastasis were 60.47%,58.97%,77.78% and 55.81%,respectively,which were significantly higher than those in patients with PSA level ≤20 ng/mL,TNM stageⅠ-Ⅱ,Gleason score <7,and no lymph node metastasis（χ~2=13.198,8.795,21.243,7.088,all P<0.05）. The total infection rate of PV 16/18 was positively correlated with PSA level,TNM stage,Gleason score and lymph node metastasis(rs=0.428,0.349,0.543,0.313,all P<0.05). The median progression free survival of HPV 16/18 infected and uninfected PCa patients was 27 months(95%CI:25.04-28.96)and 28 months(95%CI:25.17-30.83),respectively,with no significant difference（χ~2=0.244,P=0.622）. Conclusion The infection rate of HPV16/18 increased in PCA patients,which was correlated with PSA level,TNM stage,Gleason score and lymph node metastasis,but not with progression free survival.更多还原