【摘要】 目的 探讨浙北地区的季节气候因素对腹膜透析相关性腹膜炎（PDAP）的影响，为PDAP防治提供依据。方法 回顾性分析83例接受腹膜透析及发生PDAP患者的临床资料，按照PDAP发生季节分组，比较春、夏、秋、冬四组PDAP发生率、致病菌，分析PDAP发生率与月平均温度、相对湿度和降水量的相关性。结果 83例患者共发生117例次腹膜炎，夏季PDAP发生率最高，为0.34次/风险年，不同季节间PDAP发生率比较，差异有统计学意义（χ~2=21.03,P<0.05）。Pearson相关分析显示PDAP发生率与月平均温度呈正相关（r=0.80,P<0.05），但与相对湿度及月平均降水量无明显相关性（r分别=0.11、0.55,P均>0.05）。PDAP的致病菌以革兰阳性细菌为主，但各类致病菌的构成比不存在季节差异（χ~2=6.77,P>0.05）。结论 本地区PDAP发生与季节变化存在一定相关性，夏季、高温月份，PDAP发生率显著升高，需特别关注腹膜炎的预防。更多还原

【Abstract】 Objective To explore the effects of seasonal changes on peritoneal dialysis associated peritonitis(PDAP in northern Zhejiang Province,and to provide evidence for clinical prevention and treatment of PDAP.Methods The data of patients with PDAP were retrospectively analyzed.The patients were divided into four groups based on the four seasons.The incidence of PDAP,pathogens in different seasons were analyzed.Pearson correlation analysis was employed to analyze the relationship between the incidence of PDAP and climate factors,including monthly mean temperature,humidity and rainfall. Results A total of 117 PDAP episodes occurred in 83 patients.The incidence of PDAP in summer(0.34episodes/risk year)was the highest,and there was significant difference in peritonitis rate among four groups（χ~2=21.03,P<0.05）.Pearson correlation analysis showed that the incidence of PDAP had a correlation with monthly mean temperature(r=0.80,P<0.05),no correlations with monthly mean humidity(r=0.11,P>0.05)and monthly mean rainfall(r=0.55,P>0.05).Gram-positive bacteria were the most common pathogens that caused PDAP.However,the component of bacterial pathogens was similar among the four seasons （χ~2=6.77,P>0.05）.Conclusion There is some correlation between the incidence of PDAP and seasons in northern Zhejiang Province.The summer season and higher temperature are significantly correlated with higher PDAP rate,and should be paid more attention for PDAP prevention.更多还原