【摘要】 目的 系统评价风药联合西药常规治疗冠状动脉粥样硬化性心脏病（冠心病）稳定型心绞痛的有效性和安全性。方法 计算机检索中国知网（CNKI）、万方数据库（WanFang Data）、维普数据库（VIP）、中国生物医学文献数据库（SinoMed）、PubMed、Embase、The Cochrane Library、Web of Science，搜索风药联合西药常规治疗冠心病稳定型心绞痛的相关随机对照试验（RCTs），检索时限均从建库至2022年8月。由2名研究者独立筛选文献、提取资料和评价纳入研究的偏倚风险后，采用RevMan5.3软件进行Meta分析。结果 共纳入4个研究，包括278例患者，其中观察组139例（风药联合西药常规治疗），对照组139例（西药常规治疗）。Meta分析结果显示：与西药常规治疗相比，风药联合西药常规治疗冠心病稳定型心绞痛可有效改善心绞痛疗效（RR=1.46,95%CI:1.15～1.86,P=0.002），改善心电图疗效（RR=1.61,95%CI:1.18～2.19,P=0.002），结果存在统计学差异，对中医证候疗效影响不显著（RR=1.13,95%CI:1.00～1.27,P=0.05），结果无统计学差异，在不良事件发生率方面，两组无统计学差异（P>0.05），且均未发生严重不良事件。结论 风药联合西药常规治疗冠心病稳定型心绞痛较西药常规治疗的疗效更明显，且安全性较高。受纳入研究的数量和质量的限制，本研究结论尚需要开展更多高质量研究予以证实。更多还原

【Abstract】 Objectives To analyze systematically the curative effect and safety of wind-dispelling medicinal combined with routine therapy of Western medicine in treating stable angina pectoris(SAP) of coronary heart disease(CHD). Methods The databases of CNKI, WanFang Data, VIP, SinoMed, PubMed, Embase,Cochrane Library and Web of Science were retrieved for searching randomized controlled trials(RCT) related to wind-dispelling medicinal combined with routine therapy of Western medicine in treating SAP of CHD from database establishment time to Aug. 2022. All documents were screened, data was extracted and risk of bias in included RCT was reviewed by 2 researchers independently, and then a Meta-analysis was conducted by using RevMan 5.3 software. Results There were totally 4 RCT and 278 patients included, and 139 in observation group(treated with wind-dispelling medicinal combined with routine therapy of Western medicine) and 139 in control group(treated with routine therapy of Western medicine). The results of Meta-analysis showed that SAP of CHD was effectively relieved(RR=1.46, 95%CI: 1.15～1.86, P=0.002), and electrocardiogram was improved(RR=1.61, 95%CI: 1.18～2.19, P=0.002) in observation group compared with control group, but the curative effect on syndromes of traditional Chinese medicine had no significantly difference between 2 groups(RR=1.13,95%CI: 1.00～1.27, P=0.05). There was no statistical difference in incidence rates of adverse events between 2groups(P>0.05), and there were no adverse events occurred in 2 groups. Conclusion Wind-dispelling medicinal combined with routine therapy of Western medicine has more significant curative effect and higher safety in treating SAP of CHD, while as the limitation of quantity and quality of the included RCT, the conclusions of this study still need to be confirmed by more high-quality studies.更多还原