【摘要】 目的 观察生脉散加减联合机械通气治疗慢性阻塞性肺疾病急性加重期（AECOPD）患者的临床效果。方法 选取2019年4月—2021年4月石家庄市中医院收治的AECOPD患者98例，根据随机数字表法分为观察组和对照组，每组49例。对照组患者予以机械通气及常规治疗，观察组患者则在对照组基础上联合生脉散加减治疗，2组均治疗1周。比较2组患者治疗效果，治疗前后肺功能指标[第1秒用力呼气容积占预计值百分比（FEV₁%）、第1秒用力呼气容积占肺活量百分比（FEV₁/FVC）]、血气分析指标[pH值、动脉血二氧化碳分压（PaCO₂）、动脉血氧分压（PaO₂）、动脉血氧饱和度（SaO₂）]、慢性阻塞性肺疾病评估测试（CAT）评分及不良反应。结果 观察组治疗总有效率为93.88%,高于对照组的79.59%（χ²=4.346,P=0.037）。治疗1周后，2组患者FEV₁%、FEV₁/FVC较治疗前均升高，且观察组高于对照组（P均<0.01）;2组患者pH值、PaO₂及SaO₂较治疗前均升高，PaCO₂较治疗前下降，且观察组升高/下降幅度大于对照组（P均<0.01）;2组患者CAT评分均较治疗前降低，且观察组低于对照组（P均<0.01）。2组均未出现严重的药物不良反应，经停药或减量后症状消失。结论 生脉散加减联合机械通气治疗AECOPD患者的疗效较佳，可有效缓解患者肺功能，改善血气分析指标，提升患者的生活质量，且安全性较高。更多还原

【Abstract】 Objective To observe the clinical effect of Shengmai powder combined with mechanical ventilation in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）. Methods A total of 98 AECOPD patients admitted to Shijiazhuang Hospital of traditional Chinese Medicine from April 2019 to April 2021 were selected and randomly divided into observation group（49 cases） and control group（49 cases）. The control group was given mechanical ventilation and conventional treatment, while the observation group was given the addition and subtraction treatment of Shengmai powder on the basis of the control group. Two groups were treated for 1 week. The treatment effect, pulmonary function indexes（FEV₁%, FEV₁/FVC）, blood gas analysis indexes（pH, PaCO₂, PaO₂, SaO₂） and CAT score before and after treatment, and adverse reactions were compared between the two groups. Results The total effective rate of the observation group was 93.88%, higher than 79.59% of the control group（χ²=4.346, P=0.037）. After 1 week of treatment, FEV₁% and FEV₁/FVC of the two groups were higher than those before treatment, and the observation group were higher than those of the control group（P<0.01）; The pH value, PaO₂ and SaO₂ of the two groups were higher than those before treatment, PaCO₂ of the two groups were lower than those before treatment, and the increase/decrease amplitude of the observation group were greater than those of the control group（P<0.01）; The CAT score of the two groups were lower than those before treatment, and the observation group was lower than that of the control group（P<0.01）. No serious adverse drug reactions occurred in the two groups, and the symptoms disappeared after drug withdrawal or reduction. Conclusion The effect of Shengmai powder combined with mechanical ventilation in the treatment of AECOPD patients is better, which can effectively relieve patients′ pulmonary function, improve blood gas analysis indicators, improve patients′ quality of life, and has high safety.更多还原