【摘要】 本研究以1-(2-硝基苯基)乙醇、溴代烃、4-甲氧基嘧啶-5-甲酸和2-甲氧基嘧啶-4-甲酸为原料，通过醚化、还原以及酰胺化反应，合成了一系列N-(2-(1-烃氧乙基)苯基)-甲氧基嘧啶甲酰胺。初步生物活性测定表明，部分化合物在100 mg/L时对3种植物病原菌表现出中等杀菌活性:化合物6c对茄子菌核病菌的抑制率为79.6%,6d对水稻纹枯病菌的抑制率为73.5%,6b对草莓灰霉病菌的抑制率为71.8%。该研究结果为探索新型的SDHI抑制剂提供了有价值的参考。更多还原

【Abstract】 A series of N-(2-(1-alkoxyethyl)phenyl)-methoxypyrimidine-carboxamides have been synthesized using 1-(2-nitrophenyl)ethan-1-ol, alkyl bromide, 4-methoxypyrimidine-5-carboxylic acid and 2-methoxy pyrimidine-4-carboxylic acid as starting materials. The synthesis involved the etherification and the subsequent reduction, as well as the amidation reaction. The preliminary bioassay revealed that some compounds displayed moderate fungicidal activities at 100 mg/L against three plant pathogenic fungi. The inhibitory rate of compound 6c against Sclerotinia sclerotiorum was 79.6%, 6d against Rhizoctonia solani was 73.5%, and 6b against Botrytis cinerea was 71.8%. The research results provide valuable references for exploring new SDHI inhitors.更多还原