【摘要】 在哺乳动物精子发生过程中，精原干细胞(spermatogonial stem cells, SSCs)具有不同程度干细胞或祖细胞的特性。SSCs既可以进行自我更新维持干细胞池，也可以进行分化维持精子持续产生，SSCs自我更新与分化命运决定的调控机制对于雄性生殖细胞的发育过程至关重要。高度保守的早幼粒细胞白血病锌指(promyelocytic leukemia zinc finger, PLZF)蛋白作为一种多功能转录因子，已经被证明是SSCs自我更新所必需的。目前PLZF对SSC的调控作用成为了生殖及干细胞方向研究的重要课题。本文就SSC和PLZF的生物学特点与功能、PLZF对SSC的调控机制进行了综述，为探究PLZF的基因调控网络和在雄性生殖干细胞(male germline stem cells, mGSCs)发育过程中的作用提供参考。更多还原

【Abstract】 In mammalian spermatogenesis, spermatogonial stem cells(SSCs) possess the characteristics of stem cells or progenitor cells. SSCs can not only conduct self-renewal to maintain the stem cell pool, but also conduct differentiation to maintain the continuous production of sperm. Therefore, the regulatory mechanism of self-renewal and differentiation of SSCs is crucial for the development of male germ cells. At present, the regulation of SSCs has become an important topic in the reproduction and stem cell research. As a multifunctional transcription factor, the highly conserved promyelocytic leukemia zinc finger(PLZF) protein has been proved to be necessary for the self-renewal of SSCs. This review focuses on the advances of biological characteristics and functions of PLZF, and the regulatory mechanism of PLZF on SSCs, which will provid a reference for exploring the gene regulatory network of PLZF and its role in the development of male germline stem cells(mGSCs).更多还原