【摘要】 目的：探讨维吾尔族2型糖尿病（T2DM）环状RNA＿0003340的表达水平与胰岛细胞功能的关系。方法：纳入维吾尔族T2DM患者68例及正常对照者68例，测定生化指标，稳态模型评估胰岛β细胞功能指数（HOMA-β）和胰岛素抵抗指数（HOMA IR），检测外周血环状RNA＿0003340表达水平。结果：维吾尔族T2DM组环状RNA＿0003340表达水平高于对照组（P<0.01）。Spearman相关分析显示，环状RNA＿0003340表达水平与空腹血糖、2h血糖、糖化血红蛋白、甘油三酯、空腹胰岛素、HOMA-IR呈正相关（P<0.05），与HOMA-β呈负相关（P<0.01）；偏相关分析显示，环状RNA＿0003340表达水平与空腹血糖、2h血糖、糖化血红蛋白、HOMA-IR呈正相关（P<0.05）。结论：维吾尔族T2DM环状RNA＿0003340表达水平升高，且其表达水平与胰岛细胞功能存在相关性，环状RNA＿0003340表达上调可能参与了维吾尔族T2DM的发生。更多还原

【Abstract】 Objective: To investigate the correlation between expression level of circular RNA＿0003340 and islet cell function in Uygur type 2 diabetes mellitus(T2DM).Methods:68 Uygur T2DM patients and 68 Uygur normal controls were recruited. Biochemical indicators, homeostasis model assessment of islet β cell function(HOMA-β)and homeostasis model assessment of insulin resistance(HOMA-IR) were measured,and the expression level of circular RNA＿0003340 in peripheral blood was detected.Results:The expression level of circular RNA＿0003340 in Uygur T2DM patients was higher than that in normal controls(P<0.01). Spearman correlation analysis showed that the expression level of circular RNA＿0003340 was positively correlated with fasting blood glucose,2h blood glucose,glycosylated hemoglobin,triglyceride,fasting insulin,and HOMA IR(P<0.05),and negatively correlated with HOMA-β(P <0.01); Partial correlation analysis showed that the expression level of circular RNA＿0003340 was positively correlated with fasting blood glucose,2h blood glucose,glycosylated hemoglobin, and HOMA IR(P<0.05).Conclusion:The expression level of circular RNA＿0003340 is increased in Uygur T2DM patients,and its expression level is correlated with islet cell function.The up-regulated expression of circular RNA＿0003340 may be involved in the development of T2DM in Uygur patients.更多还原