【摘要】 目的:系统评价益气补肺法联合西医常规疗法治疗慢性阻塞性肺疾病(COPD)稳定期的临床疗效及安全性。方法:采用计算机和人工查找相结合的方式在WANFANG、CNKI、VIP、CBM、PubMed、Web of Science等数据库检索相关随机对照试验，检索时间限定为自各数据库建立至2022年4月30日。由2名研究员对最终纳入文献进行质量评价和数据提取后，采用Revman 5.4软件和Stata 15.1软件进行Meta分析。结果:共纳入15篇文献，1499例患者。结果显示：益气补肺法联合西医常规疗法治疗COPD稳定期疗效明确且具有诸多优势，主要包括：(1)改善患者肺功能：升高FEV1/FVC [MD=5.09,95%CI(3.43,6.74),P<0.00001]、FEV1 [MD=0.46,95%CI(0.27,0.65),P<0.00001]以及FVC [MD=0.54,95%CI(0.32,0.76),P<0.00001];(2)提高总有效率[OR=4.37,95%CI(2.96,6.46),P<0.00001];(3)提高和调节患者免疫功能：升高外周血CD4~+ T细胞比例[MD=5.36,95%CI(3.76,6.96),P<0.00001]与CD4~+/CD8~+比值[MD=0.67,95%CI(0.58,0.75),P<0.00001],降低外周血CD8~+ T细胞比例[MD=-3.44,95%CI(-4.35,-2.53),P<0.00001];(4)减缓炎症反应：降低血清TNF-α [MD=-9.83,95%CI(-10.84,-8.83),P<0.00001]和IL-8含量[MD=-12.14,95%CI(-15.52,-8.75),P<0.00001]。结论:益气补肺法联合西医常规疗法治疗COPD稳定期安全有效，但尚需更多优质临床报道进行佐证。更多还原

【Abstract】 Objective To systematically evaluate the clinical efficacy and safety of benefit Qi for tonifying lung recipes combined with conventional western medicine in treating chronic obstructive pulmonary disease(COPD) at stable stage. Methods We collected all relevant randomized controlled trials by searching databases such as WANFANG, CNKI, VIP, CBM, PubMed, Web of Science from the establishment of each database to April 30, 2022. The retrieval method is the combination of computer retrieval and manual retrieval. After evaluating the quality of finally included studies and extracting all useful data, 2 researchers used Revman5.4 software and Stata15.1 software to meta-analyze. Results Meta analysis included 15 studies, with a total of 1499 patients. The results showed that treating COPD at stable stage with benefit Qi for tonifying lung recipes combined with conventional western medicine has clear efficacy and many advantages:(1)Effectively improve pulmonary function, including improving FEV1/FVC [MD=5.09, 95%CI(3.43, 6.74), P<0.00001], FEV1 [MD=0.46, 95%CI(0.27, 0.65), P<0.00001] and FVC [MD=0.54, 95%CI(0.32, 0.76), P<0.00001].(2)Effectively improve clinical efficacy [OR=4.37, 95%CI(2.96, 6.46).(3)Significantly enhance and regulate immune function, including increasing the proportion of CD4~+ T cells in peripheral blood [MD=5.36, 95%CI(3.76, 6.96), P<0.00001] and CD4~+/CD8~+ ratio [MD=0.67,95%CI(0.58,0.75),P<0.00001], reducing the proportion of CD8~+ T cells in peripheral blood [MD=-3.44, 95%CI(-4.35,-2.53), P<0.00001].(4)Significantly retard inflammatory reaction, including decreasing serum TNF-α [MD=-9.83, 95%CI(-10.84,-8.83), P<0.00001] and IL-8 content [MD=-12.14, 95%CI(-15.52,-8.75), P<0.00001]. Conclusion Benefit Qi for tonifying lung recipes combined with conventional western medicine can treat COPD at stable stage effectively and safely, but more rigorous, standardized and highly reliable clinical reports are needed to approve it.更多还原