【摘要】 IL-33是白细胞介素1家族来源的核细胞因子，通过其受体作用于多种细胞，如肥大细胞、2型固有淋巴细胞、嗜碱性粒细胞，是2型免疫反应发生及维持的重要细胞因子之一。近年来研究表明，IL-33激活外周神经系统参与瘙痒信号的传递。本文回顾了IL-33介导受体激活的信号转导机制/2型炎症皮肤病中IL-33参与瘙痒的神经免疫机制及IL-33靶向药物研究进展。更多还原

【Abstract】 IL-33 is a nuclear cytokine of the IL-1 family, which acts on a variety of cells through combination its receptors, such as mast cells, innate lymphocytes type 2, basophils, etc.. It is one of the important cytokines in the development and maintenance of type 2 immune responses. Recent studies have shown that IL-33 is involved in pruritic signaling through activating the peripheral nervous system. This paper focuses on the signal transduction mechanism after the activation of interleukin 33 receptor, and elaborates the neuroimmune mechanism of IL-33 involved in pruritus in type 2 inflammatory skin diseases. We also review the advances of drug research targeting IL-33.更多还原