【摘要】 患者，男，50岁。右胸部红斑20余年。组织病理示：角化过度，棘层轻度增生，表皮内可见异型淋巴细胞，真皮浅层少量淋巴细胞浸润。免疫组化：CD3(+),CD4(+),CD5(+),CD8(+),CD7(+,丢失不明显),CD20(-),Ki67(表皮内个别淋巴细胞+)。T淋巴瘤克隆性基因重排检测结果：阳性。诊断为：蕈样肉芽肿(斑片期)。给予0.05%地奈德乳膏外用，4周后皮疹明显好转。更多还原

【Abstract】 A 50-year-old male presented with an erythema on the right chest for more than 20 years. Histopathological examination showed hyperkeratosis, acanthosis, a papillary dermal lymphocytic infiltrate with prominent epidermotropism by atypical lymphocytes. Immunohistochemical investigation showed that the lymphocytes were positive for CD3, CD4, CD5, CD7, CD8, and negtive for CD20. The clonal gene rearrangement test for T lymphoma was positive. The diagnosis of mycosis fungoides was made. The patient was treated with 0.05% desonide cream for 4 weeks, with good response.更多还原