【摘要】 免疫代谢近年来日益受到关注，癌基因驱动的肿瘤细胞代谢变化可影响肿瘤微环境(TME),进而抑制免疫反应，并对癌症治疗造成障碍。这提示我们可以通过靶向代谢途径改善TME,增强抗癌免疫效应。本文总结目前将TME内免疫细胞代谢转变为促炎状态的策略，并强调需要更好地还原生理条件，进而选择靶点、阐明机制和优化代谢抑制剂。更多还原

【Abstract】 The growing field of immune metabolism has revealed promising indications for metabolic targets to modulate anti-cancer immunity.Oncogene-driven changes in tumor cell metabolism can impact the TME to limit immune responses and present barriers to cancer therapy.These changes also reveal opportunities to reshape the TME by targeting metabolic pathways to favor immunity.Here we explore current strategies that shift immune cell metabolism to pro-inflammatory states in the TME and highlight the need of better replicate physiologic conditions to select targets, clarify mechanisms, and optimize metabolic inhibitors.更多还原