【摘要】 目的 拟评估使用球囊扩张式瓣膜（球扩瓣）进行经导管主动脉瓣置换术（transcatheter aortic valve replacement,TAVR）的安全性及有效性，并对初步的操作经验进行总结。方法 回顾性分析2020年9月至2020年12月在广东省人民医院使用球扩瓣进行TAVR治疗的重度主动脉瓣狭窄患者的手术效果。结果 6例患者均成功完成了TAVR。术后1个月内无不良事件发生，主动脉瓣狭窄改善明显，主动脉瓣平均跨瓣压差[（60.5±13.3）mmHg vs.(14.8±3.1)mmHg,P<0.001)](1 mmHg=0.133 kPa)和主动脉瓣峰值流速均显著减小[（4.9±0.6）m/s vs.(2.6±0.3)m/s,P<0.001]。结论 初步经验显示，使用球扩瓣对重度主动脉瓣狭窄患者进行TAVR安全有效。可调弯输送系统和短瓣架设计是球扩瓣的主要优势。更多还原

【Abstract】 Objectives To evaluate the safety and efficacy and summarize the initial experience of transcatheter aortic valve replacement(TAVR)with a balloon-expandable valve.Methods This study retrospectively analyzed the effectiveness of TAVR with a balloon-expandable valve performed in patients with severe aortic stenosis in Guangdong Provincial People’s Hospital from September 2020 to December 2020.Results TAVR procedures were successful in all 6 cases.There was no adverse event at 1 month. Aortic stenosis was alleviated significantly,with a significant reduction in mean transaortic valve pressure gradient[(60.5±13.3)mmHg vs.(14.8±3.1)mmHg,P<0.001](1 mmHg=0.133 k Pa)as well as peak aortic valve velocity[(4.9 ± 0.6)m/s vs.(2.6 ± 0.3)m/s,P<0.001].Conclusions Our preliminary experience showed that TAVR with a balloon-expandable valve is safe and effective in patients with severe aortic stenosis. A bendable deliver system and a short valve design are the main advantages of the balloon-expandable valve.更多还原