【摘要】 目的：研究地塞米松复合罗哌卡因和舒芬太尼在分娩镇痛中的疗效，对产妇及新生儿的影响。方法：按照纳入和排除标准成功纳入69例初产妇行临床试验。随机分为两组行硬膜外穿刺：A组（36例）1%盐酸罗哌卡因10 ml+舒芬太尼50μg+生理盐水89 ml。B组（33例）1%盐酸罗哌卡因10 ml+舒芬太尼50μg+地塞米松5 mg+生理盐水88 ml混合液，行VAS评分和运动神经阻滞分级，记录产妇疼痛评分和麻醉平面、产后不良反应，总给药量，新生儿结局。结果：B组比A组的镇痛时间长（P<0.05）。B组比A组需求更小剂量的罗哌卡因，差异有统计学意义（P<0.05），两组之间在血流动力学、疼痛评分、新生儿结局和并发症无差异（P>0.05）。结论：无痛分娩时硬膜外镇痛中的地塞米松具有延长的镇痛持续时间，减少麻醉药物用量，不增加母亲和婴儿不良反应。更多还原

【Abstract】 Objective:To study the analgesic effect of dexamethasone combined with ropivacaine and sufentanil on parturients during labor and the effect on parturients and neonates. Methods:According to the inclusion and exclusion criteria,we selected the women who gave birth in the Department of Obstetrics of our hospital,and successfully enrolled69 patients in the clinical trial,all of whom were primipara with cervical dilation ≥2 cm during vaginal delivery. Patients were randomly divided into two groups:Group A(36 cases)after successful epidural puncture,1% ropivacaine hydrochloride 10 ml+ sufentanil 50 μg+ normal saline 89ml. Group B(33 cases)received 10 ml of 1% ropivacaine hydrochloride+ Sufentanil 50 μg+ dexamethasone 5 mg+ 88 ml of normal saline mixture,VAS score and motor nerve block grade were performed,maternal pain score,anesthesia level,postpartum adverse reactions,total dose,neonatal outcome were recorded. Results:The duration of analgesia in group B was longer than that in group A(P<0.05). Group B required A lower dose of ropivacaine than group A,the difference was statistically significant(P<0.05),and there were no differences in hemodynamics,pain scores,neonatal outcomes and complications between the two groups(P> 0.05).Conclusion:Dexamethasone in epidural analgesia for painless delivery has an extended duration of analgesia,reduced dosage of narcotic drugs,and no increase in adverse effects for mother and baby.更多还原