原发性高血压合并2型糖尿病TyG指标与动态血压变异度相关性分析

【摘要】 目的 探讨原发性高血压合并有2型糖尿病（T₂DM）患者24 h动态血压变异度和空腹甘油三酯血糖（TyG）指数的相关性。方法 选择2021年8月至12月原发性高血压病患者140例,根据是否合并T2DM,分为单纯原发性高血压组和高血压+T₂DM组,每组各70例,所有患者行24 h动态血压监测,检测血脂,计算TyG指数和血浆致动脉硬化指数（AIP）,比较两组各监测指标的差异、分析血压变异性与TyG的相关性。结果 高血压+T₂DM组患者的收缩压、舒张压、24 h平均收缩压、24 h平均舒张压、收缩压变异系数（sCV）和舒张压变异系数（dCV）均大于单纯高血压组,差异均有统计学意义（P<0.05）。高血压+T₂DM组患者的TyG和AIP均大于单纯高血压组,差异均有统计学意义（P<0.05）。根据TyG值按中位数分成低水平组及高水平组,TyG≤4.52为低水平组,TyG>4.52为高水平组。随着TyG值增加,收缩压、舒张压、24h平均收缩压、24h平均舒张压、sCV和dCV均明显增加（P<0.05）,高血压+T₂DM组患者的收缩压、舒张压、24h收缩压及舒张压的平均水平、sCV和dCV均与TyG呈明显正相关（P<0.05）。多元线性回归分析显示24 h收缩压及舒张压的平均水平是TyG的主要影响因素。结论 高血压合并T2DM患者24 h动态血压变异度与TyG指数密切相关。关注TyG指标有助于进一步改善原发性高血压合并T₂DM患者的预后。更多还原

【Abstract】 Objective To investigate the correlation between 24 h ambulatory blood pressure variability and triglyceride glucose index(TyG index) in patients with hypertension and type 2 diabetes mellitus.Methods 140 patients with essential hypertension admitted to our hospital from August 2021to December 2021 were selected,and were divided into the simple essential hypertension group and the hypertension combined with type 2 diabetes group(70 cases each) according to whether they were combined with type 2 diabetes.All subjects underwent 24 h dynamic blood pressure monitoring and blood lipid detection.TyG index and plasma arteriosclerosis index(AIP) were calculated.The differences in monitoring indicators between the two groups were compared,and the correlarion between blood pressure variability and TyG were analyzed.Results The systolic blood pressure,diastolic blood pressure,24h mean diastolic blood pressure,systolic blood pressure,coefficient of variation of systolic blood pressure(sCV) and coefficient of variation of diastolic blood pressure(dCV) of parients with hypertension combined with type 2 diabetes were higher than those of patients with simple essential hypertension(P<0.05).The TyG index and AIP index of patients in hypertension combined with type 2 diabetes group were higher than those in simple essential hypertension group(P<0.05).According to the median TyG value,the low-level group and the high-level group were divided into two groups.TyG≤4.52 was the low-level group,and TyG>4.52 was the high-level group.The results showed that systolic blood pressure,diastolic blood pressure,24 h mean systolic blood pressure,24 h mean diastolic blood pressure,sCV and dCV increased significantly with the increase of TyG value(P<0.05).Systolic blood pressure,diastolic blood pressure,24 h mean systolic blood pressure,24 h mean diastolic blood pressure,sCV and dCV were significantly positively correlated with TyG index in patients with hypertension and type 2 diabetes mellitus(P<0.05).Multiple linear regression analysis showed that 24 h mean systolic blood pressure and 24 h mean diastolic blood pressure were the main influencing factors of TyG.Conclusion 24 h ambulatory blood pressure variation in patients with hypertension and diabetes mellitus is closely related to TyG index.Therefore,focusing on TyG index is helpful to further improve the prognosis of essential hypertension complicated with type 2 diabetes.更多还原