【摘要】 目的 建立质子泵抑制剂（PPIs）合理性评价的量化模型，为PPIs的合理性评价提供参考。方法以注射用泮托拉唑说明书为依据，参照国家相关规范，利用属性层次模型（AHM）加权后的优劣解距离法（TOPSIS），建立注射用泮托拉唑的评价方法。从合肥市第一人民医院合理用药系统中电脑随机抽取2021年1月1日至12月31日使用注射用泮托拉唑的患者归档病历，利用TOPSIS对其合理性进行评价。结果 共纳入100份病历。注射用泮托拉唑合理使用（Ci=1.0）病历占22%,1.0<Ci≤0.8占13%,Ci<0.6占65%，平均值为0.21。注射用泮托拉唑合理性最低的3个项目为适应证（35%）、给药频次（67%）和病程记录中记载用药原因（69%）。结论 基于量化模型的PPIs合理性评价方法能够发现临床使用PPIs的问题并量化表示，评价更为客观，指向问题更明确，能够更清楚地发现合理性问题的程度，可更加针对性地改善问题。更多还原

【Abstract】 Objective To establish a quantitative model for the rational evaluation of proton pump inhibitors(PPIs), providing a reference for the rational evaluation of PPIs. Methods Based on the instruction of pantoprazole injection and relevant national regulations, an evaluation method for the injection of pantoprazole was established using the attribute hierarchy model(AHM) and technique for order preference by similarity to an ideal solution(TOPSIS). The rationality evaluation was conducted on patients randomly selected from the rational drug use system of Hefei First People’s Hospital from January 1 to December 31, 2021, who used pantoprazole for injection. Results A total of 100 medical records were included. The reasonable cases(Ci=1. 0) of pantoprazole injection in the sample were 22%; 1. 0<Ci≤0. 8 accounted for 13%; those with lower than 0. 6 accounted for 65%. The average value of the sample was 0. 21. The three items with the worst rationality were indications(35%), frequency of administration(67%), and documentation of the reasons for medication in the medical records(69%).Conclusion The quantitative model-based rational evaluation method for PPIs can identify and quantify clinical issues related to the use of PPIs. The evaluation criteria are more objective and specific, which allows for clearer identification of the degree of irrationality, and thus helps to improve the issues more effectively.更多还原