【摘要】 继发性噬血细胞综合征中，32.8%～50.4%的诱因为感染。病毒，尤其是人类疱疹病毒，是最常见的病原类型。传统检测技术联合病原宏基因组检测有助于提高病原微生物的检出率，但需结合病情判定检出病原微生物和疾病间的因果关系。发热、外周血两系降低伴无其他原因的脾大、肝损伤，需警惕感染相关噬血细胞综合征。抗感染治疗是感染相关噬血细胞综合征的基础治疗。需根据病情和病原学特点制订“个体化”综合治疗方案。该文综述感染相关噬血细胞综合征的常见病原微生物种类、治疗及预后，以期提高临床救治率。更多还原

【Abstract】 Infection accounts for 32.8%-50.4% of secondary hemophagocytic syndrome. Viruses, especially human herpesvirus, are the most common pathogenic type. Traditional techniques combined metagenomic next-generation sequencing is helpful to find the pathogens, but it is necessary to determine the causal relationship between pathogens and infection-associated hemophagocytic lymphohistiocytosis(IAHLH). Awareness of IAHLH is crucial when patients with infection have unknown splenomegaly and/or liver dysfunction, fever and cytopenia. Anti-infection therapy is the basic treatment of IAHLH. "Tailored" therapy regime is based on the severity of the individual and the characteristics of the pathogen. It reviews the common pathogenic, therapy regime and prognosis of IAHLH, for the improvement of early diagnosis and survival rate.更多还原