【摘要】 目的 基于TOLL样受体4(TLR4)/核因子-κB(NF-κB)信号通路探讨肃金方联合常规药物治疗感染后咳嗽风邪犯肺证临床效果及机制。方法 选取2020年5月—2022年6月就诊的感染后咳嗽100例，按治疗方案不同分为联合组和常规组2组各50例。联合组采用肃金方联合常规药物治疗，常规组采用常规药物治疗。比较2组治疗前、治疗1周后和治疗2周后中医证候积分、咳嗽症状积分、生活质量和TLR4/NF-κB信号通路相关指标，治疗2周后效果，以及治疗期间不良反应。结果 治疗1和2周后，咳嗽、咽干、咽痒和咳痰积分，咳嗽日间和夜间积分及TLR4/NF-κB信号通路相关指标2组均低于治疗前，且联合组低于常规组；莱彻斯特咳嗽生活质量问卷评分2组均高于治疗前，且联合组高于常规组(P<0.05)。治疗2周后，总有效率联合组高于常规组(P<0.01)。治疗期间，2组不良反应发生率比较无差异(P>0.05)。结论 肃金方联合常规药物治疗感染后咳嗽风邪犯肺证患者效果良好，可改善临床症状，抑制炎性因子表达，提高生活质量，且安全性好；分析原因可能与肃金方能调控TLR4/NF-κB信号通路有关。更多还原

【Abstract】 Objective To investigate the clinical effect and mechanism of Sujin prescription combined with conventional drugs on pulmonary syndrome of coughing and wind evil after infection based on toll-like receptor 4(TLR4)/nuclear factor-κB(NF-κB) signaling pathway. Methods A total of 100 patients with postinfection cough who received medical treatment from May 2020 to June 2022 were selected and divided into combination group(n=50) and conventinal group(n=50) according to different treatment plans. The combination group was treated with Sujin prescription combined with conventional drugs, and the conventional group was treated with conventional drugs. TCM syndrome scores, cough symptom scores, quality of life and TLR4/NF-κB signaling pathway-related indexes before treatment, and at 1 week and 2 weeks after treatment as well as clinical efficacy at 2 weeks after treatment and adverse reactions during treatment were compared between the two groups. Results At 1 and 2 weeks after treatment, the scores of cough, dry pharynx, itching and sputum, daytime and nighttime cough scores and TLR4/NF-κB signaling pathway-related indexes in the two groups were lower than those before treatment, and lower in the combination group than in the conventional group. The Leicester cough quality of life questionnaire score in the two groups was higher than that before treatment, and higher in the combination group than in the conventional group(P<0.05). At 2 weeks after treatment, the total effective rate in combination group was higher than that in conventional group(P<0.01). During treatment, there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion Sujin prescription combined with conventional drugs in the treatment of patients with pulmonary syndrome of cough and wind evil after infection has good effect, which can improve clinical symptoms, inhibit the expression of inflammatory factors, and improve the quality of life, with good safety. This may be related to the regulation of TLR4/NF-κB signaling pathway by Sujin prescription.更多还原