【摘要】 目的 探讨艾司西酞普兰对抑郁首次发作患者血清催乳素水平影响的性别差异。方法 回顾性分析抑郁首次发作的住院患者121例，根据性别分为男性研究组(57例)和女性研究组(64例),收集基线期和治疗4周末的催乳素水平，收集基线期、治疗4周末和出院当日的汉密顿抑郁量表总分和副反应情况；选取与研究组相匹配的健康男性57例和女性64例设为对照组。结果 在基线期，4组催乳素水平有显著差异(P<0.01),男性研究组与男性对照组、女性研究组与女性对照组催乳素水平差异均无统计学意义(P>0.05);治疗4周末，男性研究组与女性研究组催乳素水平较基线期均升高，但只有女性研究组较基线期差异有统计学意义(P<0.05)。男性研究组和女性研究组在治疗4周末，高催乳素血症发生率分别为7.02%、20.31%,差异有统计学意义(P<0.05)。结论 艾司西酞普兰治疗的女性抑郁首次发作患者血清催乳素水平升高，且女性较男性升高明显。更多还原

【Abstract】 Objective To explore the gender differences in the influence of escitalopram on serum prolactin levels in patients with first-episode depression.Methods A total of 121 hospitalized patients with first depressive episode were retrospectively analyzed,divided into male research(n=57) and female group(n=64) according to genders,prolactin levels at baseline and at the end of 4 weeks of treatment collected,and so did the total scores on the Hamilton Depression Scale(HAMD-17) and side reactions at baseline,at the end of 4 weeks of treatment and on discharge;fifty-seven healthy males and 64 females matched with research groups were assigned to control group.Results On baseline,there were significant differences in prolactin levels among the four groups(P<0.001),differences between male research and control group as well as female research and control group had no statistical significance(P> 0.05);at the end of 4weeks of treatment prolactin levels elevated in male and female research groups compared with baseline,but difference only in female research group had statistical significance(P<0.05).At the end of 4 weeks of treatment prolactin levels in male research group and female research group were higher than those in baseline period,but there was statistical significance in female research group(P<0.05).At the end of 4weeks,the incidence of hyperprolactinemia was respectively 7.02% in male and 20.31 % in female research group,the difference was statistically significant(P<0.005).Conclusion Serum prolactin levels elevate in patients with first-episode depression and the elevation is more obvious in female than male ones.更多还原