【摘要】 目的:基于动静态盆底MRI评估女性压力性尿失禁(stress urinary incontinence, SUI)盆底结构的变化，并探讨盆底MRI相关参数对女性SUI的预测价值。方法:前瞻性收集2020年7月—2022年3月于郑州大学第一附属医院经尿动力学检查诊断为SUI患者51例作为SUI组，选取同期年龄与之相匹配的健康志愿者49例作为对照组。所有患者及健康志愿者均行动静态盆底MRI扫描，在静态和动态最大力排相上观察有无膀胱颈漏斗及尿道开放征，并测量尿道倾斜角(UIA)、膀胱颈(BN)到耻骨尾骨线(PCL)的距离(BN-PCL)、尿道中段括约肌(横纹肌和平滑肌)厚度以及功能尿道长度(FUL)、双侧耻骨直肠肌(PRM)厚度、髂尾肌(ICM)厚度、肛提肌裂孔最大横径(LHW)、提肛板角(LPA)、髂尾角(ICA)等。分析2组动静态MRI测量值的差异，筛选影响SUI发生的参数，建立ROC曲线并计算相关参数的AUC值、灵敏度、特异度、最佳阈值，并分析相关参数与尿动力学检查漏尿点压力(VLPP)的相关性。结果:膀胱尿道相关参数中，SUI组的尿道中段横纹肌厚度、静态及动态最大力排相FUL值、静态及动态最大力排相BN-PCL值均较对照组小(P<0.05);SUI组静态及动态最大力排相UIA值、UIA差值、FUL差值及BN-PCL差值均较对照组大(P<0.05);SUI组静态及动态最大力排相膀胱颈漏斗征阳性率、动态最大力排相尿道开放征阳性率均大于对照组。肛提肌相关参数中，SUI组双侧PRM厚度均较对照组小(P<0.05);SUI组LHW、静态及动态最大力排相LPA值、LPA差值均较对照组增大(P<0.05)。动态最大力排相BN-PCL、UIA、FUL和尿道开放征的AUC值分别为0.849、0.838、0.857及0.735;灵敏度分别为81.6%、78.4%、80.2%、49.0%;特异度分别为71.4%、75.5%、77.6%、98.0%。以上4个盆底参数分别进行2个、3个和4个参数组合进行ROC曲线分析时，任意参数联合诊断效能均大于单项参数，其中BN-PCL+UIA+FUL参数联合评估是预测SUI的最佳指标。动态最大力排相UIA与VLPP呈负相关(r_s=-0.431,P<0.05);动态最大力排相FUL与VLPP呈正相关(r_s=0.395,P<0.05)。结论:MRI检查可以清楚显示盆底结构变化，利用盆底多种参数联合应用分析，能够明显提高对SUI的预测效能，并为进一步探讨女性SUI发病机制提供依据。更多还原

【Abstract】 Objective: To evaluate the changes of pelvic floor structure of female stress urinary incontinence(SUI) based on dynamic and static pelvic floor MRI, and to explore the predictive value of pelvic floor MRI-related parameters for SUI. Methods: From July 2020 to March 2022, 51 patients with SUI diagnosed by urodynamic examination in First Affiliated Hospital of Zhengzhou University were prospectively collected as the SUI group, and 49 age-matched healthy volunteers were selected as the control group during the same period. All patients and healthy volunteers were scanned by static and dynamic pelvic floor MRI. The presence of bladder neck funneling and urethral opening sign were observed on static and maximal strain phase of dynamic MRI, and the urethral inclination angle(UIA), bladder neck(BN) to pubococcygeal line(PCL) distance(BN-PCL), midurethral sphincter(striated muscle and smooth muscle) thickness and functional urethral length(FUL), bilateral puborectalis muscle(PRM) thickness, iliococcygeus muscle(ICM) thickness, levator hiatus width(LHW), levator plate angle(LPA), iliococcygeal angle(ICA), etc. The differences between the two groups of dynamic and static MRI measurements were analyzed, then parameters affecting the occurrence of SUI were selected. The ROC curve was established and the AUC value, sensitivity, specificity and optimal threshold of relevant parameters were calculated. The correlation between relevant parameters and Valsalva leak point pressure(VLPP) was analyzed. Results: Among the parameters related to the bladder and urethra: the thickness of the striated muscle in the middle urethra, the FUL value of the static and maximal strain phase of dynamic MRI, and the BN-PCL value of the static and maximal strain phase of dynamic MRI of the SUI group were significantly decreased(P<0.05). The UIA and the difference of UIA, FUL and BN-PCL values between static status and maximal strain phase were significantly increased(P<0.05). The positive rate of bladder neck funnel in static status and maximal strain phase, urethral opening in maximal strain phase of SUI group increased significantly. Among the parameters related to the levator ani muscle: the bilateral PRM thickness in the SUI group were smaller than that in the control group(P<0.05). The LHW, the static and maximal strain phase LPA value and LPA difference in the SUI group were larger than those in the control group(P<0.05). The AUC values of BN-PCL, UIA, FUL and urethral opening sign on maximal strain phase of dynamic MRI were 0.849, 0.838, 0.857 and 0.735, respectively; the sensitivity were 81.6%, 78.4%, 80.2%, 49.0%; the specificity were 71.4%, 75.5%, 77.6%, and 98.0%, respectively. When the above four pelvic floor parameters were analyzed with two, three and four parameters, the combined diagnostic efficiency of any parameter was greater than a single parameter, among which the combined evaluation of BN-PCL+UIA+FUL parameters was the best index to predict SUI. The UIA on maximal strain phase of dynamic MRI was negatively correlated with VLPP(r_s=-0.431, P<0.05), while the FUL on maximal strain phase was positively correlated with VLPP(r_s=0.395, P<0.05). Conclusion: MRI examination can clearly show the structural changes of the pelvic floor. The combined application and analysis of multiple parameters of the pelvic floor can significantly improve the prediction efficiency of SUI, and provide a basis for further exploring the pathogenesis of female SUI.更多还原