【摘要】 非酒精性脂肪性肝病(NAFLD)是全世界最为常见的慢性肝病。肝脏与肠道之间有着紧密的结构及功能关系即“肠-肝轴”,其中肠道菌群可通过菌群易位、内源性乙醇的产生、胆汁酸和胆碱代谢的调节异常、内毒素血症等参与NAFLD的发生、发展。本文主要关注肠道菌群及代谢产物在NAFLD发生、发展及治疗中的作用进展。更多还原

【Abstract】 Nonalcoholic fatty liver disease(NAFLD) is the most common chronic liver disease around the world. There is a close structural and functional relationship between the liver and the intestine, namely “the gut-liver axis”, in which intestinal microbiota can participate in the development and progression of NAFLD through microbial translocation, production of endogenous ethanol, abnormal regulation of bile acid metabolism and choline metabolism, and endotoxemia. This article reviews the role of intestinal microbiota and metabolites in the development, progression, and treatment of NAFLD.更多还原