【摘要】 目的 通过在个性化钛网表面制备聚四氟乙烯膜，改善个性化钛网表面生物相容性和抗菌性能。方法 采用白刚玉对个性化钛网表面进行喷砂粗化并空气喷涂聚四氟乙烯分散液，烧结热固化成膜以获得聚四氟乙烯膜改性个性化钛网（PMTM）。实验分组为激光选区熔融打印未处理（CON）、机械抛光（MP）、低粒径喷砂（SB）、成品钛加强致密性聚四氟乙烯膜（TRDP），分析试样表面形貌、粗糙度、亲水性、官能团、物相组成。对与金黄色葡萄球菌和大肠杆菌共培养后各组试样表面黏附的细菌数量及形态进行分析，评估聚四氟乙烯膜改性个性化钛网的体外抗菌能力。结果 PMTM组表面形成稳定结合、高纯度的聚四氟乙烯薄膜，使改性的个性化钛网表面微米尺度粗糙度下降，高度疏水。CON组表面细菌量最多（P<0.001）,MP、SB组表面细菌黏附数量较低。PMTM及TRDP组细菌黏附量相对最低，两者抗细菌黏附效果相近（P>0.05）。结论 在个性化钛网表面制备聚四氟乙烯膜可以抑制细菌黏附，是一种较为理想的个性化钛网表面处理手段。更多还原

【Abstract】 Objective By preparing polytetrafluoroethylene film on the surface of customized titanium mesh, the biocompatibility and antibacterial ability of the surface of customized titanium mesh were improved. Methods The surface of the customized titanium mesh was sandblasted to roughen the surface by alumina and air-sprayed with PTFE dispersion. The polytetrafluoroethylene film modified customized titanium mesh(PMTM) was obtained by sintering and heat curing. The experimental groups were selective laser melting printing untreated group(CON), mechanical polishing group(MP), lowgrit sandblasting group(SB), titanium-reinforced dense polytetrafluoroethylene film group(TRDP). The surface morphology, roughness, hydrophilicity, functional groups and phase composition of the samples were analyzed. The number and morphology of bacteria adhering to the surface of each group of samples after co-culture with Staphylococcus aureus and Escherichia coli were analyzed to evaluate the in vitro antibacterial ability of polytetrafluoroethylene film modified customized titanium mesh. Results The polytetrafluoroethylene film with stable bonding and a high purity is formed on the surface of the PMTM group, which reduced the micron-scale roughness and is highly hydrophobic. The number of bacteria on the surface of the CON group was the largest(P<0.001), and the numbers of bacteria on the surface of the MP and SB groups were lower. The PMTM and TRDP groups had the lowest bacterial adhesion, and their antibacterial adhesion effects were similar(P>0.05). Conclusion The preparation of polytetrafluoroethylene film on the surface of customized titanium mesh can improve its ability to inhibit bacterial adhesion, which is an ideal surface treatment method for customized titanium mesh.更多还原