【摘要】 目的：分析莫西沙星致过敏性休克发生的特点与规律，为临床安全用药提供参考。方法：利用中国医院知识库（CHKD）、万方数据库和中文科技期刊全文数据库，以“莫西沙星“”过敏性休克“”休克“”不良反应“”严重过敏反应”等为关键词进行检索，筛选相关文献，分析莫西沙星致过敏性休克的发生特点与规律。结果：检索到莫西沙星致过敏性休克的病例报告22例，其中女性略多于男性（13例vs 9例），年龄上以>50～70岁（15例，占68.18%）居多；莫西沙星以口服和静脉给药导致过敏性休克的人数均为11例；莫西沙星所致过敏性休克主要发生在首次用药的30 min内（17例，占77.27%），其主要累及循环系统和中枢神经系统；莫西沙星致过敏性休克患者经对症处理后全部转归良好。结论：莫西沙星所致过敏性休克在女性和中老年患者身上发生较多，并且主要累及循环系统和中枢神经系统，临床在使用莫西沙星治疗时应加强监测，以及时应对药物不良反应的发生，减少对患者的伤害。更多还原

【Abstract】 Objective: To analyze the characteristics and regularity of moxifloxacin-induced anaphylactic shock and provide reference for clinical safe medication. Methods: The literature search was conducted by using the keywords such as "moxifloxacin", "anaphylactic shock", "shock", "adverse reaction" and "severe allergic reaction" from the China Hospital Knowledge Database(CHKD), Wanfang Database and Chinese Sci-tech Journal Full-text Database, and relevant literatures were screened, to analyze the characteristics and regularity of moxifloxacin-induced anaphylactic shock.Results: A total of 22 case reports of moxifloxacin-induced anaphylactic shock were searched, among which, the number of women was slightly more than men(13cases vs 9 cases), and most of them were elder than 50-70 years(15 cases,68.18%). There were 11 patients with anaphylactic shock caused by oral and intravenous administration of moxifloxacin.The moxifloxacin-induced anaphylactic shock mainly occurred within 30 minutes after the first administration(17 cases,77.27%), which mainly involved the circulatory system and central nervous system. All patients with moxifloxacininduced anaphylactic shock recovered well and had good outcomes. Conclusion: Moxifloxacin-induced anaphylactic shock mainly occurs in women and middle-aged and elderly patients, and mainly involves the circulatory system and central nervous system. Clinical monitoring should be strengthened when moxifloxacin is used, to deal with the adverse drug reactions in a timely manner and reduce harms to patients.更多还原