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热疗对化疗的增敏作用研究进展

Research progress on the sensitization effect of hyperthermia on chemosensitivity

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【作者】 曹鹤; 史丽颖; 于大永;

【Author】 CAO He;SHI Liying;YU Dayong;Dalian University College of Life Science and Technology;

【通讯作者】 于大永;

【机构】 大连大学生命科学与技术学院;

【摘要】 肿瘤热疗安全有效、不良反应低且与其他治疗方法有协同作用。热疗主要通过直接对肿瘤细胞产生杀伤作用和发挥增敏效应来提高放化疗作用效果,热疗对化疗的增敏作用尤为引人注目。本文回顾了近年来热疗在恶性肿瘤治疗领域中的研究,现对热疗基础及其对人组织细胞淋巴瘤、乳腺癌、胃肠道癌、皮肤癌化疗增敏机制做一梳理,为今后肿瘤的治疗方式提供参考。

【Abstract】 Tumor hyperthermia is safe and effective, with low adverse reactions, and has synergistic effect with other treatment methods. Hyperthermia mainly improves the effect of radiotherapy and chemotherapy by directly killing tumor cells and exerting sensitization effect. The sensitization effect of hyperthermia on chemotherapy is particularly remarkable. This article reviews the research of hyperthermia in the field of malignant tumor treatment in recent years. We reviewed the basis of hyperthermia and its mechanism of chemosensitization for human tissue cell lymphoma, breast cancer, gastrointestinal cancer and skin cancer, so as to provide reference for tumor treatment in the future.

【关键词】 肿瘤热疗; 化疗; 增敏; 机制;
【Key words】 tumor hyperthermia; chemotherapy; sensitization; mechanism;
【基金】 辽宁省科学技术计划(2019-ZD-0564)
  • 【文献出处】 河南大学学报(医学版) ,Journal of Henan University(Medical Science) , 编辑部邮箱 ,2023年01期
  • 【分类号】R730.5
  • 【下载频次】52
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