【摘要】 目的 研究恶性肿瘤患者骨转移及其他脏器转移时血清骨唾液酸蛋白（bone sialoprotein,BSP）、I型胶原氨基末端肽（N-terminal telopeptide of type I collagen,NTx）的水平变化。方法 收集天津市第四中心医院肿瘤血液科2013年9月至2014年9月间收治的资料完整的恶性肿瘤患者49例，其中无转移组（CO组）17例，其他脏器转移组（CM组）15例，骨转移组（CB组）17例，酶联免疫吸附法（enzyme-linked immunosorbent assay,ELISA）试剂盒检测BSP、NTx血清水平。结果 1)CB组BSP水平明显高于CO及CM组[分别为（4 305.45±964.83）pg/mL、（3 302.50±748.67）pg/mL、（3 326.34±920.94）pg/mL]，且组间差异有统计学意义（P值分别为0.002、0.007）。2)CB组NTx水平明显高于CO及CM组[分别为（58.66±14.33）ng/m L、（39.24±12.62）ng/m L、（47.71±15.49）ng/m L]，且组间差异有统计学意义（P值分别为<0.001、0.047）。3)CO与CM组之间BSP及NTx水平近似，组间差异无统计学意义（P值分别为0.963、0.099）。结论 血清BSP及NTX水平测定可以作为临床早期监测恶性肿瘤骨转移的特异性指标，试验方法简单，操作方便，有利于临床上广泛开展。更多还原

【Abstract】 Objective To study the changes of serum bone sialoprotein(BSP) and N-terminal telopeptide of type I collagen(NTx) levels in patients with malignant tumor with bone metastasis and other organ metastasis. Methods A total of 49 patients with malignant tumor with complete data admitted to oncology and hematology department of tianjin fourth center hospital from September 2013 to September 2014 were collected, including 17 patients without metastasis in the CO group, 15 patients with other organ metastasis in the CM group, and 17 patients with bone metastasis in the CB group, serum levels of BSP and NTx were detected by enzymelinked immunosorbent assay(ELISA). Results 1) The level of BSP in CB group was significantly higher than that in CO and CM groups [(4 305.45±964.83) pg/mL,(3 302.50±748.67) pg/mL and(3 326.34±920.94) pg/mL, respectively], the differences between the groups were statistically significant(P values were 0.002 and 0.007, respectively). 2) The level of NTx in CB group was significantly higher than that in CO and CM groups [(58.66±14.33) ng/mL,(39.24±12.62) ng/mL and(47.71±15.49) ng/mL, respectively], and the differences between groups were statistically significant(P values <0.001 and 0.047, respectively). 3) The levels of BSP and NTx were similar between CO and CM groups, but there was no statistical significance between groups(P values were 0.963 and 0.099, respectively). Conclusion The serum levels of BSP and NTx can be used as specific indicators for the early clinical monitoring of malignant tumor with bone metastasis, the testing method is simple and convenient to operate, which is conducive to use in clinic.更多还原