【摘要】 慢性肾脏病(CKD)是一种进展性疾病，具有高发病率和高病死率的特点。目前，终末期肾脏病患者(ESRD)除了接受透析和肾移植外，无其他有效的治疗方法，而肾源的稀缺和肾脏替代治疗所带来的巨大经济压力都是目前无法攻克的难题。肾纤维化是慢性肾脏病的主要病理表现，有效控制肾纤维化对CKD的防治至关重要。血栓调节蛋白(TM)是一种具有明确的抗炎、抗凝作用的跨膜蛋白，近年发现TM还具有抗细胞凋亡和抗纤维化的生物特性，这意味着其在CKD预防、治疗中的巨大潜力。文章就TM功能及其在肾脏疾病中发挥的作用和机制进行综述，深入探讨TM与肾脏疾病的关系和相关机制，以期为肾脏疾病的诊断和治疗提供新思路。更多还原

【Abstract】 Chronic kidney disease(CKD) is a progressive disease with high morbidity and mortality.At present, there is no effective treatment for patients with end-stage renal disease except for dialysis and kidney transplantation.However, the scarcity of kidney sources and the huge economic pressure brought by renal replacement are the insurmountable difficulties.Renal fibrosis is the main pathological manifestation of CKD,and effective control of renal fibrosis is vital for the prevention and treatment of CKD.Thrombomodulin(TM) is a transmembrane protein with definite anti-inflammatory and anticoagulant effects.In recent years, TM has also been found to have anti-apoptotic and anti-fibrotic properties, suggesting a great potential of TM in the prevention and treatment of CKD.This article reviews the role and mechanism of action of TM in renal diseases and explores the relationship between TM and kidney disease, in order to offer new ideas for the diagnosis and treatment of kidney diseases.更多还原