【摘要】 研究光果甘草根提取物/二葡糖基棓酸/伸长海条藻提取物经皮共输送纳米载体(臻耀白)的细胞摄取、抗氧化和美白功效。臻耀白平均粒径为42.2±1.4nm,多分散系数(PDI)为0.189±0.007,Zeta电位为-27.1±0.8mV。臻耀白可显著提高黑素细胞对活性成分的摄取量；可降低活性氧(ROS)水平，抑制B16F10细胞的酪氨酸酶活性和黑素生成；可降低黑素合成相关基因转录水平，从而减少黑素的产生。臻耀白作为新型美白功效原料具有良好的应用前景。更多还原

【Abstract】 The cellular uptake, antioxidant and whitening efficacy of glycyrrhiza glabra extract/diglucosyl gallate/elongated seaweed extract was investigated on a transdermal co-delivery nanocarrier(Zhenyaobai).The average particle size was 42.2±1.4nm, the PDI was 0.189±0.007 and the zeta potential was-27.1±0.8mV.It inhibits the tyrosinase activity and melanin content of B16F10 cells and reduces the level of transcription of genes related to melanin synthesis, thereby reducing melanin production.The study shows that Zhenyaobai has good potential as a new whitening ingredient.更多还原