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基于多模态融合注意力的肝细胞癌疗效预测方法

Prediction method of hepatocellular carcinoma efficacy based on multimodal fusion attention

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【作者】 文含付忠良赵莹姚宇刘爱连

【Author】 WEN Han;FU Zhongliang;ZHAO Ying;YAO Yu;LIU Ailian;Chengdu Institute of Computer Applications,Chinese Academy of Sciences;University of Chinese Academy of Sciences;The First Affiliated Hospital of Dalian Medical University;Dalian Medical Imaging Artificial Intelligence Engineering Technology Research Center;

【通讯作者】 刘爱连;

【机构】 中国科学院成都计算机应用研究所中国科学院大学大连医科大学附属第一医院大连市医学影像人工智能工程技术研究中心

【摘要】 针对传统方法预测肝细胞癌(HCC)疗效通常只采用图像信息、临床信息或基因信息等单一模态信息的问题,提出一种基于多模态融合注意力的HCC疗效预测方法。首先,使用残差网络(ResNet)提取图像特征和多层感知机提取临床特征和常规放射学特征;其次,构建一个多模态融合注意力模块,通过计算不同模态特征之间的相关性有效地融合图像特征、临床特征和常规放射学特征;最后,通过一个分类网络实现对HCC患者疗效的准确分类预测。实验结果表明,与单一模态预测疗效的方法相比,所提方法的准确率在实验数据集上提升了5.95个百分点,验证了所提方法能显著改善HCC患者疗效预测的结果。

【Abstract】 A multimodal fusion attention-based HepatoCellular Carcinoma(HCC) efficacy prediction method was proposed to address the problem that traditional methods for predicting the efficacy of HCC usually use single modal information such as image information,clinical information,or genetic information.Firstly,Residual Network(ResNet) was used to extract image features,and a multi-layer perceptron was employed to extract clinical and conventional radiological features.Then,a multimodal fusion attention module was constructed to efficiently fuse image features,clinical features,and conventional radiological features by calculating the correlation between different modal features.Finally,a classification network was used to accurately predict and classify HCC patient outcomes.The experimental results show that compared to the single-modality method for predicting efficacy,the accuracy of the proposed method increases by 5.95 percentage points on experimental dataset,confirming that the proposed method can significantly improve the prediction results of HCC patient efficacy.

【基金】 国家自然科学基金资助项目(61971091,82073338);四川省科技计划项目(2022YFS0384);大连市青年科技之星项目(2022RQ074);大连市医学科学研究计划项目(2212011)
  • 【文献出处】 计算机应用 ,Journal of Computer Applications , 编辑部邮箱 ,2023年S2期
  • 【分类号】TP391.41;R735.7
  • 【下载频次】44
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