【摘要】 子痫前期是复杂的妊娠特异性疾病,严重者会引起HELLP综合征(溶血、肝酶升高和血小板减少),是孕产妇和婴幼儿死亡的主要原因。转化生长因子β1(TGF-β1)是具有多种生物活性的多肽生长因子,已被证明是胚胎发育和调节滋养层细胞活动所需的多功能细胞因子,在母胎免疫稳态、血管形成及血管张力调控中发挥着重要作用。因此,TGF-β1可能成为子痫前期的生物标记物。更多还原

【Abstract】 Preeclampsia is a complex pregnancy-specific disease that can seriously cause HELLP syndrome(hemolysis, elevated liver enzymes, and thrombocytopenia), which is the main cause of maternal and infant mortality. Transforming growth factor β1(TGF-β1) is a polypeptide growth factor containing a variety of biological activities. It has been proved to be a multifunctional cytokine required for embryonic development and regulation of trophoblast cell activities, and plays an important role in maternal-fetal immune homeostasis, angiogenesis and regulation of vascular tension. Therefore, TGF-β1 may be a biomarker for preeclampsia.更多还原