【摘要】 目的：探讨动态对比增强磁共振成像（DCE-MRI）的定量参数在直肠癌分化程度及血管侵犯评估中的价值。方法：前瞻性分析经术前内镜下病理证实为直肠腺癌并行DCE-MRI扫描的43例患者，其中高分化腺癌12例，中分化20例，低分化11例；有血管侵犯13例，无血管侵犯30例。使用Tofts模型测定各定量参数，即血管外细胞外间隙容积分数（V_e）、血管内至血管外间隙转运系数(K^trans)、血管外间隙返回至血管内速率常数(K_ep)。比较高、中、低分化组及有无血管侵犯组的V_e、K^trans、K_ep。结果：K^trans及V_e在高、中、低分化组中差异均有统计学意义（均P<0.05）,K_ep差异无统计学意义（P>0.05）。血管侵犯组与无血管侵犯组的K_ep差异有统计学意义（P<0.05）,K^trans及V_e差异均无统计学意义（均P>0.05）。结论：DCE-MRI定量参数可用于评估直肠癌的分化程度及血管受侵犯情况。更多还原

【Abstract】 Objective:To investigate the value of quantitative parameters of dynamic contrast-enhanced MRI （DCE-MRI） for the differentiation degree,vascular invasion of rectal cancer.Methods:A total of 43 patients with rectal adenocarcinoma confirmed by preoperative endoscopic pathology were enrolled in a prospective analysis,and all patients underwent DCE-MRI scan.In43 patients,12 cases were well differentiated adenocarcinoma,20 were moderately differentiated and 11 were poor differentiated;13 cases were with vascular invasion and 30 without vascular invasion.The perfusion parameters,V_e,K^transand K_ep,were determined by the Tofts model and compared among different differentiated subgroups and with/without vascular invasion subgroups.Results:The K^transand V_evalues were significantly different among different differentiated subgroups （P<0.05）,while the K_epvalue was not significantly different （P>0.05）.The K_epvalue was significantly different between the vascular invasion subgroup and the non-invasion subgroup （P<0.05）,while the K^transand V_evalues were not significantly different （both P>0.05）Conclusion:DCE-MRI quantitative parameters can be used to evaluate the differentiation degree and vascular invasion of rectal cancer.更多还原