【摘要】 骨关节炎是一种常见的关节退变性疾病，软骨细胞凋亡是其主要的病理生理改变，而内质网应激(ER stress)在其中发挥了不可忽视的作用。为了限制内质网应激带来的不利影响，细胞会激活未折叠蛋白质应答(UPR)。然而当内质网应激持续存在超过UPR所能承受的最大限度时，细胞会通过UPR的3条通路引发内质网功能障碍从而导致软骨细胞凋亡。更多还原

【Abstract】 Osteoarthritis is a common degenerative disease in which endoplasmic reticulum stress(ER stress) plays an important role in the pathogenesis of chondrocyte apoptosis. To limit the adverse effects of endoplasmic reticulum stress, cells activate the unfolded protein response(UPR). However, when endoplasmic reticulum stress persists beyond the maximum tolerance of UPR, cells may trigger endoplasmic reticulum dysfunction through three pathways of UPR leading to chondrocyte apoptosis.更多还原