【摘要】 间充质干细胞来源的外泌体(MSC-EXOs)携带着脂质、蛋白、核酸等信号物质，在细胞间通讯、免疫调节、血管再生中发挥着重大作用。MSC-EXOs在肺动脉高压、肺纤维化等肺部疾病中通过调控不同的信号通路、减少细胞炎性反应、调节免疫细胞功能、改善线粒体功能、促进血管生成、减轻肺血管重构等途径改善肺组织的功能，治疗肺部疾病，从而为今后难治性肺部疾病的治疗提供新思路。更多还原

【Abstract】 Exosomes secreted by mesenchymal stem cell(MSC-EXOs)carry lipids, proteins, nucleic acids and other signaling substances, which play an important role in intercellular communication, immune regulation and vascular regeneration. MSC-EXOs in pulmonary hypertension, pulmonary fibrosis and other lung diseases can improve the function of the lung tissue and treat lung diseases by regulating different signaling pathways, reducing cell inflammatory reaction, regulating immune function, improving the function of mitochondria, promoting angiogenesis, reducing pulmonary vascular remodeling and etc.,which provides new ideas for the treatment of refractory lung diseases in the future.更多还原