【摘要】 目的 评价深圳市学龄前儿童水痘抗体水平，为水痘疫苗免疫策略提供科学依据。方法 采取分层随机抽样的方法，采集深圳市学龄前儿童血样，采用酶联免疫吸附测定(enzyme linked immuno sorbent assay, ELISA)测定血清中水痘抗体滴度，分析接种剂次、接种间隔等不同免疫状态对水痘IgG抗体几何平均浓度(geometric mean concentration, GMC)、抗体阳性率的影响。结果 深圳市学龄前儿童水痘IgG抗体GMC为11.20 U/mL,阳性率为61.5%。未接种组、接种1次组和接种2次组的GMC分别为4.31 U/mL、12.15 U/mL、15.86 U/mL(F=11.11,P<0.001),抗体阳性率分别为26.1%、39.5%和74.5%(χ~2=41.42,P<0.001);第1针及时接种组和超期接种组GMC分别为14.17 U/mL、8.07 U/mL(t=3.11,P=0.002),抗体阳性率分别为70.8%、47.9%(χ~2=11.12,P<0.001)。结论 深圳市学龄前儿童及时地完成第2针疫苗接种可提高免疫抗体水平。更多还原

【Abstract】 Objective To evaluate the level of varicella antibody in preschool children in Shenzhen, and to provide a scientific basis for effective varicella vaccine immunization strategy. Methods Blood samples were collected from preschool children in Shenzhen through stratified random sampling. The varicella antibody titer in the serum was measured using an enzyme-linked immunosorbent assay. The influence of different immunization conditions, such as the number of vaccinations and the interval between vaccinations, on the geometric mean concentration(GMC) and positive rate of varicella IgG antibody was analyzed. Results The GMC of chickenpox IgG antibody in preschool children in Shenzhen was 11.20 U/ml, and the positive rate of chickenpox IgG antibody was 61.5%. The GMC of chickenpox IgG antibody in non-vaccinated group, once vaccinated group and twice vaccinated group were 4.31 U/ml, 12.15 U/ml and 15.86 U/ml, respectively(F=11.11, P<0.001). And the positive rate of chickenpox IgG antibody was 26.1%, 39.5% and 74.5% in these groups, respectively(χ~2= 41.42, P<0.001); The GMC of chickenpox IgG antibody in the first needle timely vaccination group and extended vaccination group were 14.17 U/ml and 8.07 U/ml, respectively(t=3.11, P=0.002), with positive rate of 70.8% and 47.9%, respectively(χ~2=11.12, P<0.001). Conclusions Timely completion of the second vaccination for preschool children in Shenzhen can improve the antibody levels.更多还原