【摘要】 目的 在北京市人群中开展骨退行性疾病(bone degenerative diseases, BDD)研究，以了解北京市BDD人群患病情况及影响因素。方法 采用方便抽样，招募自愿参与且年龄在18～<65岁的北京市常住人群进入北京BDD研究。采用问卷收集受试者的一般人口学资料，同时对受试者进行体格检查、生化检查和骨科专科体检，并开展影像学检查。运用多因素logistic回归模型分析BDD影响因素。结果 共纳入879名研究对象，年龄为(39.79±9.12)岁。共有697人患有BDD,占总人数79.29%。多因素logistic回归模型分析显示，高龄人群患BDD的风险较高。与18～<35岁组相比，35～<50岁组与50～<65岁组BDD患病的OR值(95%CI)分别为2.684(1.845～3.904)与13.898(4.807～40.176)。超重和肥胖者与体质指数(body mass index, BMI)正常者相比，OR值(95%CI)分别为1.209(0.811～1.801)和1.768(1.030～3.035)。已婚者患病风险显著高于未婚/离异/丧偶者，其OR值(95%CI)为1.924(1.271～2.912)。结论 北京市18～<65岁人群BDD检出率较高。应加强在已婚、高年龄段、超重和肥胖者中BDD的宣传及体检。更多还原

【Abstract】 Objective The Beijing bone degenerative diseases(BDD) study aims to investigate the prevalence and factors associated with BDD among the population in the Beijing area. Methods We recruited the volunteers aged 18-<65 years who were residents of Beijing using convenience sampling. Participants completed a questionnaire about demographic information, and underwent physical, biochemical examinations, orthopedic examinations and imagological examination. Multivariate logistic regression was used to identify the influencing factors associated with BDD. Results A total of 879 participants with an average age of(39.79±9.12) years were included in the BDD study. A total of 697 subjects had BDD, accounting for 79.29% of the whole participants. Multivariate logistic regression analysis showed that the risk of bone degenerative diseases was higher in older age groups. Compared to the 18-<35 age group, the OR value(95% CI) for BDD were 2.684(1.845-3.904) for the 35-<50 age group, and 13.898(4.807-40.176) for the 50-<65 age group. The OR value(95% CI) of BDD in overweight and obesity participants, compared to normal BMI, were 1.209(0.811-1.801) and 1.768(1.030-3.035), respectively. Married participants had a significantly higher risk of BDD than unmarried/divorced/widowed participants, with an OR value(95% CI):1.924(1.271-2.912). Conclusions The prevalence of BDD among Beijing residents aged 18-<65 years is much higher. The promotion and physical examination of BDD should be strengthened for married, elderly, overweight and obese people.更多还原