【摘要】 目的 分析1990―2019年我国不同性别甲状腺癌死亡趋势，探讨性别趋势差异原因及高危人群。方法 收集并整理全球健康数据交换库中1990―2019年我国5～<95岁不同性别甲状腺癌的死亡数据。运用年龄-时期-队列(age-period-cohort, APC)模型分析年龄、时期、出生队列对甲状腺癌死亡率变化的影响。结果 1990―2013年男性甲状腺癌标化死亡率持续上升，在2013年达到最大值后逐渐下降。女性甲状腺癌年龄标化死亡率呈持续下降趋势。APC模型结果显示：男性与女性的净漂移值分别为1.38%、-2.94%。我国不同性别甲状腺癌的死亡风险均随着年龄的增长而增大，男性“J”字形上升趋势更为明显；男性甲状腺癌的死亡风险随着时期和出生队列推移而增大，女性则相反。结论 男性年龄标准化死亡率呈先上升后逐渐下降趋势，女性年龄标准化死亡率呈持续下降的趋势。越早出生的高龄女性甲状腺癌死亡风险越高，越晚出生的高龄男性死亡风险越高。更多还原

【Abstract】 Objective This study aims to analyze the trends in thyroid cancer mortality among males and females in China from 1990 to 2019, and to explore the underlying causes of the gender-based trend disparities and identify high-risk groups. Methods Thyroid cancer mortality data of males and females aged 5-<95 years in China from 1990 to 2019 were collected and collated from the Global Health Data Exchange. Age-period-cohort(APC) model was used to analyze the influence of age, period and cohort on the mortality of thyroid cancer. Results The standardized mortality rate of male thyroid cancer continued to rise from 1990 until it peaked in 2013, after which it started to decline gradually. Meanwhile, the age-standardized mortality rate of female thyroid cancer consistently decreased. APC model showed that the net drift of males and females was 1.38% and-2.94%, respectively. Both genders demonstrated an increase in thyroid cancer death risk with age, with the ascending trend of the “J” shape being more pronounced in men. In males, the risk of thyroid death increased with time and cohort, while that of females decreased with time and cohort. Conclusions The age-standardized mortality rate of thyroid cancer among men first increased and then gradually declined, whereas it continuously decreased among women. Older women, particularly those born earlier, demonstrated a higher risk of dying from thyroid cancer. Meanwhile, older men, especially those born more recently, were found to have an elevated risk of death.更多还原