【摘要】 目的 探究非酒精性脂肪肝（NAFLD）与认知功能障碍的关系。方法 在中国知网、万方数据库、维普网、中国生物医学文献数据库、PubMed、Web of Science、Embase、Cochrane Library数据库，检索NAFLD与认知功能障碍相关性的临床研究，按照纳排标准筛选、评估文献并提取资料，采用StatMP 17软件进行Meta分析。结果 共纳入13篇文献，共计73 219例患者。Meta分析结果显示，NAFLD与认知功能障碍存在相关性（OR=1.49,95%CI=1.16～1.92,P<0.05）。亚组分析结果显示，在横断面研究（OR=2.14,95%CI=1.24～3.67,P<0.05）、北美洲地区（OR=1.61,95%CI=1.32～1.98,P<0.05）、影像学/病理学诊断方法（OR=1.58,95%CI=1.04～2.41,P<0.05）、脂肪肝指数诊断方法（OR=1.60,95%CI=1.13～2.26,P<0.05）、简易精神状态检查（OR=1.35,95%CI=1.01～1.82,P<0.05）、轻度认知功能障碍（OR=1.41,95%CI=1.05～1.90,P<0.05）患者中，NAFLD与认知功能障碍呈正相关。结论 NAFLD与认知功能障碍相关，对今后如何有效预防和控制NAFLD人群发生认知功能障碍有指导意义。更多还原

【Abstract】 Objective To explore the correlation between non-alcoholic fatty liver disease(NAFLD) and cognitive impairment. Methods The research on the correlation between NAFLD and cognitive impairment was searched on China National Knowledge Infrastructure, WanFang Data, VIP, China Biology Medicine, PubMed, Web of Science, Embase, and Cochrane Library. This study screened and evaluated literature according to inclusion criteria, and extracted data. Meta-analysis was performed using StatMP 17 software.Results A total of 13 articles were included, with a total of 73 219 patients. The meta-analysis showed a correlation between NAFLD and cognitive impairment with a statistically significant [OR=1.49, 95%CI(1.16, 1.92), P < 0.05]. The subgroup analysis revealed that in cross-sectional studies [OR=2.14, 95%CI(1.24, 3.67), P<0.05], North America [OR=1.61, 95%CI(1.32, 1.98), P<0.05], imaging/pathological diagnostic methods [OR=1.58, 95%CI(1.04, 2.41), P<0.05], fatty liver index diagnostic methods [OR=1.60, 95%CI(1.13, 2.26), P<0.05], and Mini Mental State Examination [OR=1.35, 95%CI(1.01, 1.82), P<0.05] and patients with mild cognitive impairment [OR=1.41, 95%CI(1.05, 1.90), P < 0.05], NAFLD was positively correlated with cognitive impairment, and the differences were statistically significant. Conclusions NAFLD is related to cognitive impairment, which has guiding significance for effectively preventing and controlling cognitive dysfunction in NAFLD populations.更多还原