【摘要】 目的 分析影响食管小细胞癌患者接受非手术治疗的预后因素。方法 回顾性选取2012年10月—2020年12月福建省肿瘤医院51例病理确诊的食管小细胞癌患者的临床资料。统计患者的无进展生存期（PFS）、生存期（OS），并采用Kaplan-Meier法单因素分析及COX回归模型分析年龄、性别、吸烟、饮酒、病理、分段、TNM分期、化疗周期数、放疗、一线治疗后疗效评价、进展原因等因素对患者生存时间的影响。结果 单因素分析中，无放疗的食管小细胞癌非手术治疗患者生存时间中位数是13个月，要显著低于放疗患者的生存时间中位数31个月，差异有统计学意义（χ~2=11.264,P=0.001）。COX回归分析结果：放疗是食管小细胞癌非手术治疗患者生存时间的独立影响因素（HR=0.32,95%CI:0.13～0.80,P=0.01），其他因素不是食管小细胞癌非手术治疗患者生存时间的独立影响因素。结论 放疗是影响食管小细胞癌非手术治疗患者预后的独立因素。更多还原

【Abstract】 Objective To analyze the prognostic factors of patients with esophageal small cell carcinoma receiving non-surgical treatment. Methods From October 2012 to December 2020, 51 patients with esophageal small cell carcinoma diagnosed by pathology in Fujian Cancer Hospital were retrospective selected of clinical data. Progression-free survival(PFS) and survival(OS) were analyzed. Kaplan-Meier univariate analysis and COX regression model were used to analyze the effects of age, gender, smoking, alcohol consumption, pathology, staging, TNM staging, number of chemotherapy cycles, radiotherapy, efficacy evaluation after first-line treatment, and cause of progression on the survival time of patients. Results In univariate analysis, the median survival time of patients treated without radiotherapy was 13 months, which was significantly lower than the median survival time of patients treated with radiotherapy(31months),and the difference was statistically significant(χ~2=11.264, P=0.001). COX regression analysis showed that radiotherapy was an independent factor for survival time of patients treated with non-surgical treatment for esophageal small cell carcinoma(HR=0.32, 95%CI: 0.13-0.80, P=0.01), while other factors were not independent factors for survival time of patients treated with non-surgical treatment for esophageal small cell carcinoma. Conclusion Radiotherapy is an independent factor affecting the prognosis of patients with esophageal small cell carcinoma treated without surgery.更多还原