【摘要】 目的 探讨无烟艾灸对哮喘（classic asthma, CA）患儿肺功能及血清白细胞介素-6(IL-6)、IL-17、IL-33、血管内皮生长因子（VEGF）表达的影响。方法 回顾性选取2018年1月—2021年12月于右江民族医学院附属医院确诊并收治的100例CA患儿的临床资料，根据1∶1简单随机数表法将患儿分为观察组（n=50）和对照组（n=50）。两组均行平喘、解痉对症处理，在此基础上对照组予以沙美特罗替卡松吸入剂治疗，观察组在其基础上联合应用无烟艾灸，持续干预2周。治疗后比较两组临床疗效、肺功能水平、炎症和血管内皮功能水平。结果 治疗后观察组与对照组总有效率（94.00%vs 92.00%）比较，差异无统计学意义（χ~2=0.000,P=1.000）。治疗后观察组用力肺活量（FVC）、一秒钟用力呼气容积（FEV1）均明显高于对照组，差异有统计学意义（t=2.682、2.863,P<0.05）。治疗后观察组血清IL-6、IL-17、IL-33、VEGF及一氧化氮（NO）均显著低于对照组，差异有统计学意义（t=3.359、3.209、2.585、3.083、2.464,P<0.05）。结论 无烟艾灸联合治疗与单纯西药治疗CA患儿的疗效相当，但无烟艾灸联合治疗可以更好地降低血清炎症水平，并改善肺功能。更多还原

【Abstract】 Objective To investigate the effects of smokeless moxibustion on lung function and expression of serum interleukin-6(IL-6), IL-17, IL-33, and vascular endothelial growth factor(VEGF) in children with asthma(CA).Methods Retrospective analysis of clinical data of 100 children with CA diagnosed and admitted to the Affiliated Hospital of Youjiang Medical University for Nationalities from January 2018 to December 2021 were used as the subjects of this study. and were divided into observation group(n=50) and control group(n=50) according to 1:1 simple random number table method. Both groups were treated with symptomatic treatment of wheezing and antispasmodic, and the control group was treated with salmeterol fluticasone on this basis. In the observation group, smokeless moxibustion was applied in combination with the treatment for 2 weeks. After treatment, the clinical efficacy, lung function level,inflammation and vascular endothelial function level of the two groups were compared. Results The total effective rate in the observation group compared with the control group after treatment(94.00% vs 92.00%) was not statistically significant(χ~2=0.000, P=1.000). The exertional spirometry(FVC) and expiratory volume in one second(FEV1) were significantly higher in the observation group than in the control group after treatment, the difference was statistically significant(t=2.682, 2.863, P<0.05). Serum IL-6, IL-17, IL-33, VEGF and nitric oxide(NO) were significantly lower in the observation group than in the control group after treatment, the difference was statistically significant(t=3.359,3.209, 2.585, 3.083, 2.464, P<0.05). Conclusion The efficacy of smokeless moxibustion combination therapy was comparable to that of western medicine alone for children with CA, but smokeless moxibustion combination therapy could better reduce serum inflammation levels and improve lung function.更多还原