【摘要】 目的 探讨急性胰腺炎(AP)患者入院24 h内外周血白蛋白(ALB)/纤维蛋白原(FIB)比值(AFR)、中性粒细胞与淋巴细胞比值(NLR)、血清淀粉酶(AMY)水平变化及临床意义。方法 选取87例AP患者纳入AP组(重症38例，轻症49例),并根据患者28天预后情况分为存活组72例，死亡组15例。另选取同期性别与年龄相匹配的健康人群60例作为对照组。AP组于入院24 h内、对照组于健康体检时取外周血，检测AFR、NLR、AMY水平，比较不同组别差异，采用Pearson相关性分析AFR、NLR、AMY水平与急性生理学及慢性健康状况评分Ⅱ(APACHEⅡ)的相关性，通过ROC评估其对疾病病情程度及预后评估价值。结果 AP组、重症组、死亡组AFR水平分别低于对照组、轻症组、存活组，NLR、AMY水平分别高于对照组、轻症组、存活组(P<0.05)。APACHEⅡ评分与AFR水平呈负相关，与外周血NLR、AMY水平呈正相关(P<0.05)。AFR、NLR、AMY联合检测AUC值高于各项指标单独检测值(P<0.05)。结论 AP患者入院24 h内外周血AFR水平降低，NLR、AMY水平升高，且3项指标水平与患者疾病严重程度及其预后相关。更多还原

【Abstract】 Aim To explore the changes and clinical significance of peripheral blood serum albumin(ALB)/fibrinogen(FIB) ratio(AFR), neutrophil to lymphocyte ratio(NLR), and serum amylase(AMY) within 24 hours in patients with acute pancreatitis. Methods 87 AP patients were included, with 38 severe cases and 49 mild cases. They were divided into survival group(72 cases) and death group(15 cases) according to the 28-day prognosis of the patients, and 60 healthy people matching gender and age at the same period were selected as control group. AFR, NLR and AMY levels in peripheral blood collected from AP group within 24 h after admission and from control group during physical examination were detected. The differences among different groups were compared, Pearson correlation was used to analyze the correlation between AFR, NLR and AMY levels and acute physiology and chronic health status scoreⅡ(APACHEⅡ), and the value of AFR, NLR and AMY in evaluating disease severity and prognosis was evaluated by ROC.Results AFR level in AP group, severe group, death group was lower than that in control group, mild group, survival group, respectively, NLR and AMY levels were higher than those in control group, mild group, survival group, respectively(P<0.05). APACHEⅡ score was negatively correlated with AFR level, and positively correlated with NLR and AMY level(P<0.05). AFR, NLR, AMY AUC value of combined detection was higher than that of individual detection of each index(P<0.05). Conclusion The level of AFR in peripheral blood of AP patients was decreased and the level of NLR and AMY was increased within 24 hours after admission. The expression levels of these indicators were correlated with the disease severity and prognosis of patients.更多还原