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黄酮类化合物抗肿瘤活性及机制的研究进展
Research progress on anti-tumor activity and mechanism of flavonoids
【摘要】 黄酮类化合物的抗肿瘤作用已成为研究热点。迄今已发现8000种黄酮类化合物具有抗癌作用。现综述主要黄酮类化合物的抗肿瘤药理学的相关研究,并阐述其在肺癌、乳腺癌、胃癌、结直肠癌等肿瘤中表现出的调节炎症反应和氧化应激损伤的潜在抗肿瘤机制,为其研究、开发及临床应用提供理论依据。
【Abstract】 The anti-tumor effect of flavonoids has become a hot spot in tumor prevention and treatment research.To date, 8000 flavonoids have been found to have anticancer effects.This paper reviewed relevant studies on the antitumor pharmacology of major flavonoids, and elaborated on their modulation of inflammatory response and oxidative stress injury in lung, breast, gastric, colorectal cancer and other tumors.The potential anti-tumor mechanisms of flavonoids provides theoretical basis for the research, development and clinical application of flavonoids.
【关键词】 黄酮类化合物;
肺癌;
乳腺癌;
胃癌;
结直肠癌;
抗肿瘤作用;
炎症反应;
氧化应激;
【Key words】 Flavonoids; Lung cancer; Breast cancer; Gastric cancer; Colorectal cancer; Antitumor effects; Inflammation; Oxidative stress;
【Key words】 Flavonoids; Lung cancer; Breast cancer; Gastric cancer; Colorectal cancer; Antitumor effects; Inflammation; Oxidative stress;
【基金】 兰州市新冠肺炎防控技术研究项目(2020-XG-37)
- 【文献出处】 华西药学杂志 ,West China Journal of Pharmaceutical Sciences , 编辑部邮箱 ,2023年02期
- 【分类号】R96
- 【下载频次】775