【摘要】 有机室温磷光材料具有长发光寿命的三重态激子，相比于金属磷光体系其毒性低、生物相容性好、可设计性好，在生物成像应用中展现出独特的优势。近年来，通过磷光分子设计以及聚集方式的调控，成功开发了一系列高亮度、长寿命的有机室温磷光体系，为制备具有生物相容性且性能稳定的有机室温磷光纳米材料奠定了基础。本文系统地总结了室温磷光纳米材料的两亲性分子包裹、主客体作用、纳米聚合、有机-无机纳米杂化等构筑策略及机理，重点概括了已发展的室温磷光稳定的纳米聚集体体系和其特殊光物理性能，并展示了磷光纳米材料在细胞成像、组织成像、寿命成像、长余辉成像等领域独特的生物应用，并对有机室温磷光纳米生物材料的发展方向进行了展望。更多还原

【Abstract】 Organic room temperature phosphorescent(RTP)materials have triplet excitons with a long luminescence lifetime, with the advantages of low toxicity, good biocompatibility, and good designability compared to metal phosphorescent systems, holding unique potential in bioimaging applications. In recent years, a series of organic RTP materials with high luminance and long lifetimes have been obtained through phosphorescent molecular-structure design and aggregation-behavior modulation, laying a foundation for preparing biocompatible and stable organic RTP nanomaterials. In this review, the construction strategies and mechanism of amphiphilic molecular wrapping, host-guest interaction, nanopolymerization, and organic-inorganic nanohybridization of RTP nanomaterials were systematically summarized, the focus was on summarizing the developed RTP-stabilized nanoaggregate systems and their special photophysical properties and showcasing the unique biological applications of phosphorescent nanomaterials in fields such as cell confocal imaging, tissue hypoxia imaging, lifetime imaging and in vivo long-afterglow imaging. The prospective development direction of organic room temperature organic RTP nanobiomaterials was also discussed.更多还原