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白及在创面修复中的作用机制研究

Action Mechanism of Baiji (Bletilla striata) in Wound Repair Treatment

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【作者】 张连杰; 袁晓菲; 孙庆;

【Author】 ZHANG Lianjie;YUAN Xiaofei;SUN Qing;Shandong University of Traditional Chinese Medicine;Ji′nan Hospital of Traditional Chinese Medicine;

【通讯作者】 孙庆;

【机构】 山东中医药大学; 济南市中医医院;

【摘要】 白及作为创面修复的常用药,含有多种活性成分,不仅具有凝血止血、抑制炎性反应、抗脂质过氧化、抑菌、增强免疫功能等多种作用,还能直接影响上皮细胞、角质形成细胞、新生脉细血管、成纤维细胞和胶原等。研究发现,白及的制剂差异会影响机体对白及的吸收和释放过程,进而影响时效关系;且白及成分多样,仅凭单一成分在机体内的含量反映其对机体的剂量与功效关系,数据价值有限,对其用量问题应视不同机体、不同病情、不同制剂具体分析;白及在创面修复不同阶段、不同病理生理过程中的具体作用有待深入研究。今后可在中医传统理论的指导下,在前期实验及临床研究工作的基础上,深入研究白及对创面修复的影响,探讨其与创面愈合不同阶段影响因素之间可能的相关性,为白及在创面愈合中的合理用药提供依据。

【Abstract】 As a common drug for wound repair, Baiji(Bletilla striata) contains a variety of active ingredients, which not only have various functions such as coagulation and hemostasis, inhibition of inflammatory reaction, anti-lipid peroxidation, bacteriostasis, and enhancement of immune function, but also directly affect epithelial cells, keratinocytes, neovascular vessels, fibroblasts and collagen.It is found that the difference in the preparation of Baiji(Bletilla striata) affects the process of absorption and release of Baiji(Bletilla striata),which in turn affects the relationship between timeliness.Moreover, the components of Baiji(Bletilla striata) are diverse, and the content of a single ingredient in the body reflects the relationship between its dose and efficacy to the body, and the data value is limited, and its dosage should be analyzed according to different bodies, different diseases, and different preparations; The specific role of Baiji(Bletilla striata) in different stages of wound repair and different pathophysiological processes needs to be further studied.In the future, under the guidance of traditional Chinese medicine theory, on basis of previous experimental and clinical research work, the influence of A.alba on wound repair can be studied further, and the possible correlation between it and the influencing factors at different stages of wound healing can be explored, so as to provide a basis for the rational use of drugs in wound healing.

【关键词】 白及; 创面修复; 作用机制;
【Key words】 Baiji(Bletilla striata); wound repair; action mechanism;
【基金】 山东省名老中医药专家传承工作室建设项目{鲁卫中发展字[2018]1号};全国名老中医药专家传承工作室建设项目{国中医药人教发[2016]42号};2021年度山东省中医药科技发展计划项目(G-216)
  • 【文献出处】 中医学报 ,Acta Chinese Medicine , 编辑部邮箱 ,2023年01期
  • 【分类号】R285
  • 【下载频次】60
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