【摘要】 目的：观察佩连麻黄方加味联合穴位埋线治疗单纯性肥胖胃热湿阻证的临床疗效。方法：将60例单纯性肥胖胃热湿阻证患者按随机数字表法分为对照组和治疗组各30例，对照组患者予生活方式干预及穴位埋线治疗，治疗组在对照组基础上口服佩连麻黄方加味，治疗周期为12周。比较两组患者临床疗效、中医证候积分、肥胖相关指标（体质量、BMI、腰臀比）、胰岛素抵抗指数、血脂水平（胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白）及脂肪细胞因子（脂联素、瘦素）。结果：治疗组脱落1例患者，对照组脱落2例患者。治疗组总有效率为86.21%(25/29)，对照组总有效率为78.57%(22/28)。治疗组疗效优于对照组，差异有统计学意义（P<0.05）。两组患者治疗后中医证候积分、体质量、BMI、腰臀比、胰岛素抵抗指数、胆固醇、低密度脂蛋白及血清瘦素均较治疗前下降（P<0.05），且治疗组患者治疗后上述指标均低于对照组（P<0.05）；两组患者治疗后血清脂联素均较治疗前升高（P<0.05），且治疗组患者治疗后血清脂联素高于对照组（P<0.05）。结论：佩连麻黄方加味联合穴位埋线治疗单纯性肥胖胃热湿阻证临床疗效确切，可有效控制患者肥胖程度，缓解中医证候，改善胰岛素抵抗，调节血脂及脂肪细胞因子表达。更多还原

【Abstract】 Objective: To observe the clinical effect of Modified Peilian Mahuang Decoction(MPLMHD combined with acupoint catgut embedding on simple obesity with stomach heat and damp obstruction syndrome.Methods: A total of 60 patients with simple obesity of stomach heat and damp obstruction syndrome were divided into control group and treatment group according to random number table, 30 cases in each group. The control group was treated with lifestyle intervention and acupoint catgut embedding therapy, while the treatment group was orally administrated with MPLMHD, in addition to the control group. The treatment cycle was 12weeks. The clinical efficacy, TCM syndrome scores, obesity-related indicators(body weight, BMI and waist-to-hip ratio), insulin resistance index, blood lipid levels(cholesterol, triglycerides, high-density lipoprotein and low-density lipoprotein), and adipocytokines(adiponectin and leptin) between the two groups were compared. Results: One patient fell off in the treatment group and two patients fell off in the control group. The total effective rates of patients in the treatment group and the control group were 86.21%(25/29) and 78.57%(22/28) respectively, the differences were statistically significant(P<0.05). After treatment, the TCM syndrome scores, body weight, BMI,WHR, insulin resistance index, cholesterol, LDL and serum leptin of patients in the two groups were significantly lower than those before treatment(P <0.05), the above indexes in the treatment group were lower than those in the control group(P<0.05). After treatment, the serum adiponectin in both groups was higher than that before treatment(P<0.05), and the serum adiponectin in the treatment group was higher than that in the control group(P <0.05). Conclusion: The clinical effect of MPLMHD combined with acupoint catgut embedding has a definite clinical effect in patients with simple obesity of stomach heat and damp obstruction syndrome,which can effectively control the degree of obesity, significantly alleviate the TCM syndrome, improve insulin resistance, and regulate of blood lipids and adipocytokine expression.更多还原