【摘要】 目的 探究锶-89联合碘-131在分化型甲状腺癌骨转移治疗中的效果。方法 选取2018年6月至2022年12月郑州大学第一附属医院收治的甲状腺骨转移患者共计86例，采用随机数表法将上述研究对象平均划分为观察组(48例)、对照组(48例)。对照组患者接受手术切除甲状腺癌后使用碘-131进行治疗；观察组接受手术切除甲状腺癌后锶-89联合碘-131进行治疗。统计两组研究对象的治疗总有效率、治疗前后的血清甲状腺球蛋白(Tg)水平、疼痛视觉模拟评分(VAS)、骨转移病灶缩小面积比率以及不良反应发生率，并进行比较。结果 观察组患者的治疗有效率高于对照组患者，差异有统计学意义(P<0.05)。两组接受治疗前，Tg以及VAS评分差异无统计学意义(P>0.05);接受治疗后，上述指标相比治疗前均出现下降，且观察组低于对照组(P<0.05)。观察组骨转移病灶缩小面积比率高于对照组，差异有统计学意义(P<0.05)。两组研究对象接受治疗后，并发症发生率差异无统计学意义(P>0.05)。结论 锶-89联合碘-131能够提高分化型甲状腺癌骨转移的治疗有效率，且不增加不良反应发生风险，具有较高的应用价值。更多还原

【Abstract】 Objective To explore the curative effect of strontium-89 combined with iodine-131 on bone metastasis in differentiated thyroid cancer.Methods A total of 96 patients with thyroid bone metastasis admitted to the First Affiliated Hospital of Zhengzhou University were enrolled between June 2018 and December 2022. According to random number table method, they were divided into observation group(48 cases) and control group(48 cases). Control group was treated with iodine-131 after surgical resection of thyroid cancer. The observation group was treated with strontium-89 combined with iodine-131 after surgical resection of thyroid cancer. The total response rate of treatment, level of serum thyroglobulin(Tg), score of visual analogue score(VAS) and proportion of bone metastasis lesion reduction before and after treatment, and incidence of adverse reactions in the two groups were statistically analyzed and compared.Results The response rate of treatment in observation group was higher than that in control group(P<0.05). Before treatment, there was no significant difference in Tg or VAS score between the two groups(P>0.05). After treatment, Tg and VAS score were decreased in both groups, which were lower in observation group than control group(P<0.05). The proportion of bone metastasis lesion reduction in observation group was higher than that in control group(P<0.05). There was no significant difference in the incidence of complications between the two groups after treatment(P>0.05).Conclusion Strontium 89 combined with iodine-131 can improve response rate in the treatment of bone metastasis in differentiated thyroid cancer, which will not increase the risk of adverse reactions.更多还原